Patterns of joint behavior useful for juvenile arthritis classification

(HealthDay)—An algorithm that can classify patients with juvenile idiopathic arthritis (JIA) into seven distinct groups based on patterns of swollen or painful joints in the body can help predict disease course, according to a study published online Feb. 26 in PLOS Medicine. Simon W.M. Eng, from the University of Toronto, and colleagues used unsupervised machine learning to uncover data-driven joint […]

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Researchers engineer T cells to recognize tumor-specific expression patterns, enhancing tumor response

The advent and advancement of T cell therapy, especially chimeric antigen receptor (CAR)-modified T cells, has demonstrated therapeutic potential in treating previously treatment-resistant tumors. However, few CAR targets are absolutely tumor-specific, resulting in “on-target, off-tumor” toxicities that can be severe. Researchers in the Center for Cell and Gene Therapy at Baylor College of Medicine, Texas Children’s Hospital and Houston Methodist […]

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