Rapid tissue donation program offers feasible approach to improve research

Precision medicine with targeted therapies has led to improved treatment options and patient outcomes. These approaches were developed by studying tumors grown in laboratories and patient samples obtained before and during their treatment. However, there is often a limited supply of patient samples to adequately study, and the samples that exist do not always tell the complete genetic story of […]

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New way of measuring white blood cell function offers better insights to help patients with sepsis

Caring for a patient with sepsis requires walking a treatment tightrope. Clinicians must identify the pathogen that is causing a patient’s infection, carefully monitor the patient’s response to antibiotics and supportive measures and race against the clock to prevent potential organ failure and death. Most of the time, physicians can control the infection itself. What ultimately leads to multi-organ system […]

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Newly characterized molecule offers possibilities for novel Alzheimer’s treatments

Alzheimer’s disease is an increasingly prevalent, neurodegenerative condition that erodes memory and other cognitive functions. Treatments for this complex disease have been elusive, although researchers have previously uncovered its main biological features: amyloid-beta plaques and tau tangles. A study by researchers from Brigham and Women’s Hospital (BWH), recently published in Acta Neuropathologica, investigated lesser-known molecules involved in tauopathies like Alzheimer’s. […]

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Rhesus macaque model offers route to study Zika brain pathology

Rhesus macaque monkeys infected in utero with Zika virus develop similar brain pathology to human infants, according to a report by researchers at the California National Primate Research Center and School of Veterinary Medicine at the University of California, Davis, published June 20 in Nature Communications. Rhesus macaques may be a suitable model system to study how Zika virus infection […]

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Early, intensive treatment of RA offers long-term benefits, may normalise mortality rates

The results of a 23-year, follow-up study presented today at the Annual European Congress of Rheumatology (EULAR 2018) suggest early, intensive treatment of rheumatoid arthritis has long-term benefits including the normalisation of mortality to levels consistent with the general population. “We know that the adverse effects of rheumatoid arthritis on the body only become truly apparent after more than a […]

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‘Lone wolf’ protein offers new pathway to cancer treatments

Structural biologists at St. Jude Children’s Research Hospital have discovered how a key protein functions to trigger cell’s suicide machinery, called apoptosis. The scientists found that the protein, called BOK, is controlled separately from the rest of the apoptosis process—offering the potential for new drugs to more selectively kill cancer cells. Led by Tudor Moldoveanu, Ph.D., an assistant member of […]

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Research offers insights into impact of chronic pain

Drawing on her personal and academic background, Dr. Godfrey’s research has revealed that chronic pain does not impair how people pay attention to threatening information or their ability to focus when distractions are present. Dr. Godfrey conducted several studies based on the assumption that chronic pain would impair the way people pay attention to information that is relevant to pain. […]

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Radiotherapy offers new treatment option for liver cancer

A novel technique that delivers high doses of radiation to tumors while sparing the surrounding normal tissue shows promise as a curative treatment option for patients with early-stage liver cancer, according to a study published online in the journal Radiology. Curative treatment options for early-stage hepatocellular carcinoma (HCC), the most common type of liver cancer, include surgery, liver transplantation and […]

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Targeted radiotherapy for breast cancer offers good quality of life and fewer side effects

Quality of life for women treated with a more targeted radiotherapy treatment – called accelerated partial breast irradiation – is at least as good as quality of life for women treated with standard radiotherapy, according to research presented at the ESTRO 37 conference and published simultaneously in The Lancet Oncology. The treatment uses small tubes to deliver a higher dose […]

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