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A clot in the retinal vein can lead to severe and irreversible loss of vision. In a report in the American Journal of Pathology investigators utilize a newly developed model of central retinal vein occlusion (CRVO) in mice that mimics many of the clinical features of CRVO in humans to study the pathologic effects of retinal occlusion and demonstrate the […]
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Spice Girl Mel B recently revealed that she had the inside of her vagina “scraped” to get rid of all traces of her ex-husband, Stephen Belafonte. If that term makes you clench your legs, you’re not alone. Now, ob-gyns everywhere are taking to the internet to tell women to never, ever have their vagina scraped…seriously, never. In a December interview with The Guardian to […]
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Monoamine oxidase (MAO) inhibitors are potential drug candidates for treating neurological disorders such as anxiety, Alzheimer’s disease and Parkinson’s disease. This review presents information about MAO inhibitory effects of the umbelliferone based derivatives. The potential antioxidant effects of the derivatives were evaluated by DPPH and H2O2 scavenging methods. The derivatives were screened for hMAO-A and hMAO-B inhibition through a series […]
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Catastrophe actor Rob Delaney and his wife, Leah, recently revealed that they welcomed their fourth child — a son — in August, only seven months after the devastating loss of their 2-year-old, Henry, who died from brain cancer. This December, Delaney told the U.K.’s The Sunday Times Magazine, “We likely would’ve had a fourth anyway. But I mean, there’s mixed feelings. It’s […]
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(HealthDay)—Two drugs have been approved by the U.S. Food and Drug Administration for the treatment of rare blood diseases, the agency announced Friday. Elzonris (tagraxofusp-erzs) infusion was granted the first approval for the treatment of blastic plasmacytoid dendritic cell neoplasm (BPDCN) in adults and children aged 2 years and older. Researchers investigated the efficacy of Elzonris in two patient cohorts […]
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(HealthDay)—Patient-centered care is emphasized in updated clinical practice recommendations from the American Diabetes Association 2019 Standards of Care, published as a supplement to the January issue of Diabetes Care. The Standards of Care include new and revised recommendations for the diagnosis and treatment of children and adults with diabetes. The authors also address strategies to prevent or delay type 2 […]
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Using a mouse model of necrotizing enterocolitis (NEC)—a potentially fatal condition that causes a premature infant’s gut to suddenly die—researchers at Johns Hopkins say they have uncovered the molecular causes of the condition and its associated brain injury. The discovery enabled the team to combine efforts with colleagues studying brain inflammation and to identify potential drugs that reverse the brain […]
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Gemcitabine given in combination with nab-paclitaxel is the standard of care for patients with advanced pancreatic cancer. This practice, however, rests on data obtained from several recent clinical trials enrolling patients with pancreatic cancer who skewed younger and in better overall condition than most. Currently, there is limited data regarding the management of patients who are older and in worse […]
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A Vanderbilt University Medical Center (VUMC) study published today in JAMA shows that patients already at higher risk for gastrointestinal bleeding gain a marked protection from this risk when they take a proton pump inhibitor (PPI) in combination with an oral anticoagulant. Oral anticoagulants, which prevent blood clot formation, are among the most widely prescribed medications in the United States. […]
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Researchers from the Department of Pharmacology at the University of Seville have recently published a study reporting that diets supplemented with aqueous extract of Annona muricata L. leaves can prevent symptoms associated with fibromyalgia, improving the lives of patients. Leaves of the species are oblong and egg-like or oblong and elliptical in shape, and between five and 15 cm in […]
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