New assay assesses multiple cellular pathways at once

A novel technological approach developed by researchers at Baylor College of Medicine expands from two to six the number of molecular pathways that can be studied simultaneously in a cell sample with the dual luciferase assay, a type of testing method commonly used across biomedical fields. Published in the journal Nature Communications, the report shows that multiplexed hextuple luciferase assaying, […]

Continue reading »

Researchers find risk factors for unemployment with multiple sclerosis vary by age

A recent study by Kessler Foundation researchers explored numerous factors that contribute to the high unemployment rate among individuals of different ages with multiple sclerosis (MS). This is the first investigation to consider age within the context of disease- and person-specific factors affecting employment in MS. The article, “Unemployment in multiple sclerosis across the ages: How factors of unemployment differ […]

Continue reading »

Overall survival worse with multiple primary melanomas

(HealthDay)—Patients with multiple primary melanomas have worse overall survival than those with a single primary melanoma, according to a study published online June 26 in JAMA Dermatology. Mary-Ann El Sharouni, M.D., from the University Medical Center Utrecht in the Netherlands, and colleagues described the epidemiologic features of multiple primary melanoma in a retrospective population-based cohort study. Adults with histologically proven, […]

Continue reading »

Pediatric onset multiple sclerosis study examines baffling, often-overlooked disease

Seemingly overnight, healthy children develop mysterious, potentially disabling symptoms. When children finally receive a diagnosis, often after weeks of tests and office and hospital visits, the parents may be shocked to learn that they have multiple sclerosis—a potentially disabling autoimmune disease once believed to affect only adults. “For many years, the tagline for MS was that it was the ‘leading […]

Continue reading »

Immune cells trigger OCD-like behaviour in multiple sclerosis, study finds

A class of cells that defends the body against invaders also triggers obsessive-compulsive behaviour that appears in autoimmune disorders such as multiple sclerosis (MS), a new study from the Indian Institute of Science (IISc) has found. Autoimmune disorders, in which the body’s immune system goes rogue and attacks healthy cells, are difficult to treat. MS, for example, is a debilitating […]

Continue reading »

Multiple pregnancies might make women’s cells ‘age’ faster

Multiple pregnancies might make women’s cells age more quickly, a new Northwestern University study suggests. Led by Calen Ryan and Christopher Kuzawa of Northwestern and Dan Eisenberg at the University of Washington, the research could help explain why women with many children tend to show signs of accelerated aging. The findings, published this week in Scientific Reports, were reached by […]

Continue reading »

Single surface protein boosts multiple oncogenic pathways in acute myeloid leukemia

Researchers from the Albert Einstein College of Medicine in New York have discovered that a signaling protein elevated in patients with acute myeloid leukemia (AML) plays a much wider role in the disease than previously thought. The study, which will be published May 17 in the Journal of Experimental Medicine, raises hopes that current efforts to target this signaling protein […]

Continue reading »
1 2