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Eating watermelon in the form of powdered supplements helped adult obese mice avoid some detrimental health effects of an unhealthy diet, according to a new Oregon State University study. The study is published in the Journal of Nutrition. A significant next step in this research would be a human clinical trial, said study co-author Neil Shay, professor of food science […]
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Researchers have discovered in mice how one of the few genes definitively linked to schizophrenia, called SETD1A, likely confers risk for the illness. Mice genetically engineered to lack a functioning version of the enzyme-coding gene showed abnormalities in working memory, mimicking those commonly seen in schizophrenia patients. Restoring the gene’s function corrected the working memory deficit. Counteracting the gene’s deficiencies […]
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A new approach to treat advanced breast cancer shuts down the growth of cells that become resistant to standard hormone therapy, according to Duke Cancer Institute animal studies. The research, which is likely to be tested in clinical trials within the year, identified and targeted vulnerabilities that appear in nearly all estrogen-positive breast cancers that develop resistance to current treatments. […]
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Columbia researchers have restored normal working memory to a mouse model of schizophrenia, eliminating a core symptom of the disorder that, in people, has proven virtually impossible to treat. Working memory is a fundamental brain process used to retain and recall information on the fly, such as remembering a new phone number long enough to dial it. It is severely […]
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A team of researchers from Canada, the U.S. and Sweden has found that editing a gene involved in producing proteins that promote muscle strength in muscular dystrophy mice models could reduce symptoms. In their paper published in the journal Nature, the group describes their experiments with mice and what they learned from them. Muscular dystrophy is an inherited condition in […]
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Only a few cases of the newly discovered Bourbon virus have been reported, and two of them ended in death, partly because no specific treatments are available for the tick-borne illness. Now, researchers at Washington University School of Medicine in St. Louis have identified an experimental antiviral drug that cures mice infected with the potentially lethal virus. The drug, favipiravir, […]
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A team of researchers affiliated with multiple institutions across Germany has discovered a new type of blood vessel in mouse bones. In their paper published in the journal Nature Metabolism, the group describes making sample mouse bones transparent, as well as their microscopic properties. Christopher Ritchlin and Iannis Adamopoulos with the University of Rochester and the University of California, respectively, […]
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Immune cells engineered to attack childhood cancers were able to eradicate different types of pediatric tumors in mice, according to a new study from the Stanford University School of Medicine. The study, which will be published online Jan. 17 in Clinical Cancer Research, provides evidence that these engineered cells can target many types of pediatric solid tumors, including brain tumors. […]
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Fungal infections are emerging as a major medical challenge, and a team led by researchers at Baylor College of Medicine has developed a mouse model to study the short-term consequences of fungal infection in the brain. The researchers report in the journal Nature Communications the unexpected finding that the common yeast Candida albicans, a type of fungus, can cross the […]
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A team of researchers at the University of California has found that bacteria residing in the guts of mice are mainly obtained from their mothers and their microbiome makeup remains nearly the same over many generations. In their paper published in the journal Science, the group describes their experiments with house mice and what they learned. Prior research has shown […]
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