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Cancer-promoting genes MYC and TWIST1 co-opt immune system cells to enable cancer cells to spread, but blocking a key step in this process can help prevent the disease from developing. These findings, published today in eLife, may help clinicians to identify cancer patients at risk of metastasis, a process where cancer cells spread to other parts of the body. They […]
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(HealthDay)—The risk of nodal metastasis is five-fold greater for skin cancer on the vermilion lip versus the cutaneous lip, according to a study published online May 2 in JAMA Dermatology. David M. Wang, from Case Western Reserve University in Cleveland, and colleagues compared differences in risks of recurrence, metastasis, and death from cutaneous squamous cell carcinoma (cSCC) on the vermilion […]
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Cancer is most devastating when it metastasizes—when tumor cells break away, travel through the bloodstream, and then attach elsewhere, only to grow another tumor. A significant amount of scientific research has focused on finding ways to prevent metastasis. For some time, scientists have understood that a particular biochemical pathway, known as the PDK1 pathway, is active in metastasizing cancer cells. […]
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Jean-François Côté, a researcher at the Montreal Clinical Research Institute (IRCM) and professor at Université de Montréal’s Faculty of Medicine, studies metastasis, the leading cause of cancer-related death. Recently, his team uncovered a protein that, once deactivated, could prevent the development of metastases in an aggressive type of cancer, HER2-positive breast cancer. One in eight women will be diagnosed with […]
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According to new research conducted in mice by Whitehead Institute scientists, surgery in breast cancer patients, which while often curative, may trigger a systemic immunosuppressive response, allowing the outgrowth of dormant cancer cells at distant sites whose ability to generate tumors had previously been kept in check by the immune system. Taking a non-steroidal anti-inflammatory drug (NSAID) around the time […]
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