Researchers tie metabolic enzyme to obesity and fatty liver disease

Researchers from Clemson University’s Environmental Toxicology Program have published research connecting an enzyme associated with detoxification to obesity and fatty liver disease, especially in males. William Baldwin, professor and graduate program coordinator in the College of Science’s department of biological sciences, and members of his laboratory used a novel mouse model developed in their laboratory to study the role of […]

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New yeast model of metabolic disorders may lead to life-saving therapies

There are hundreds of metabolic disorders—including phenylketonuria, tyrosinemia, maple syrup urine disease and homocystinuria. These disorders lead to congenital diseases that produce a critical enzyme deficiency that interferes with the body’s metabolism. The pathologies and symptoms vary among the diseases, but all of them are usually fatal and have no known cure. Most metabolic disorders affect infants. The majority of […]

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High variability in metabolic measures may up mortality

(HealthDay)—High variability in metabolic parameters is associated with increased risk for mortality and cardiovascular events, according to a study published online Oct. 1 in Circulation. Mee Kyoung Kim, M.D., Ph.D., from the Catholic University of Korea in Seoul, and colleagues used nationally representative data from the Korean National Health Insurance System for 6,748,773 people who were free of diabetes mellitus, […]

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Cells in ‘little brain’ have distinctive metabolic needs

Cells’ metabolic needs are not uniform across the brain, researchers have learned. “Knocking out” an enzyme that regulates mitochondria, cells’ miniature power plants, specifically blocks the development of the mouse cerebellum more than the rest of the brain. The results are scheduled for publication in Science Advances. “This finding will be tremendously helpful in understanding the molecular mechanisms underlying developmental […]

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Natural sugar defends against metabolic syndrome, in mice

New research, in mice, indicates that a natural sugar called trehalose blocks glucose from the liver and activates a gene that boosts insulin sensitivity, reducing the chance of developing diabetes. Activating the gene also triggers an increase in calories burned, reduces fat accumulation and weight gain, and lessens measures of fats and cholesterol in the blood. The findings, from researchers […]

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Selection of a pyrethroid metabolic enzyme CYP9K1 by malaria control activities

Researchers from LSTM, with partners from a number of international institutions, have shown the rapid selection of a novel P450 enzyme leading to insecticide resistance in a major malaria vector. In a paper published in PNAS the team of researchers led by LSTM’s Professor Janet Hemingway describe how operational malaria control activities, and a move back to pyrethroid based indoor […]

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Metabolic syndrome common with chronic hep B infection

(HealthDay)—Metabolic syndrome (MetS) is prevalent among patients with chronic hepatitis B (HBV) infection, according to a study published online March 29 in Diabetes Care. Mandana Khalili, M.D., from the University of California, San Francisco, and colleagues assessed prevalence of MetS and its influence on alanine aminotransferase (ALT) levels and fibrosis among a multiethnic North American cohort with chronic HBV infection […]

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