medulloblastoma: Archives - Family Medicine News

Protein analysis uncovers new cancer subtypes for medulloblastoma

11.09.2018 Health Problems

Two patients with the same kind of tumor can have very different experiences. One patient’s cancer may progress quickly while the other grows slowly. Treatments may shrink tumors or have no effect at all. And some patients survive while others don’t. Efforts to profile tumors at the DNA, RNA, or epigenetic levels have revealed subtypes of tumors that help oncologists […]

Reviving the protector—new tactic against medulloblastoma

11.06.2018 Health Problems

Scientists have a new tactic with potential for fighting medulloblastoma, the most common and most aggressive form of brain tumor in children. The results are scheduled for publication in Cancer Cell. Several emerging anticancer treatments are called “epigenetic therapies,” targeting the ways cancer cells shut off genes that could restrain their growth. The new tactic revives a protective gene called […]

Trial identifies a medulloblastoma subset that requires less aggressive therapy

17.05.2018 Health Problems

The youngest patients with the brain tumor medulloblastoma are among the most challenging because their rapidly developing brains limit treatment options. Now a team of researchers led by St. Jude Children’s Research Hospital have discovered a subtype that responds to a therapy that is less likely to cause long-term cognitive problems. The report appears today in the journal Lancet Oncology […]

Genetic counseling and testing proposed for patients with the brain tumor medulloblastoma

10.05.2018 Health Problems

Researchers have identified six genes that predispose carriers to develop the brain tumor medulloblastoma and have used the discovery to craft genetic counseling and screening guidelines. The study appears today in the journal The Lancet Oncology. St. Jude Children’s Research Hospital, Hopp Children’s Cancer Center at the NCT Heidelberg (KiTZ), Germany, and The Hospital for Sick Children, Toronto, led the […]

PD-L1 expression in medulloblastoma: An evaluation by subgroup

02.05.2018 Health Problems

This study evaluated the expression of PD-L1 and markers of immune mediated resistance in human medulloblastoma, the most common malignant pediatric brain tumor. In cell lines, SHH MB, which are low-MYC expressing, demonstrated both constitutive and inducible expression of PD-L1 while those in Group 3/4 that expressed high levels of MYC had only inducible expression. MB expresses low levels of […]