Study discovers new molecular mechanism likely involved in cancer metastasis

Cancer is most devastating when it metastasizes—when tumor cells break away, travel through the bloodstream, and then attach elsewhere, only to grow another tumor. A significant amount of scientific research has focused on finding ways to prevent metastasis. For some time, scientists have understood that a particular biochemical pathway, known as the PDK1 pathway, is active in metastasizing cancer cells. […]

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Research finds new mechanism that can cause the spread of deadly infection

Scientists at the University of Birmingham have discovered a unique mechanism that drives the spread of a deadly infection. Cptococcosirys is a rare and deadly fungal infection that affects the lung and brain and usually only occurs in people with impaired immunity. However, one strain of the fungus – known as the Pacific Northwest strain of Cryptococcus gattii – has […]

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Mechanism that drives development of liver cancer brought on by non-alcoholic fatty liver disease discovered

A team of researchers from several institutions in China has found a mechanism that appears to drive the development of a type of liver cancer not caused by alcohol consumption. In their paper published in the journal Science Translational Medicine, the group describes their study of liver cancer in mouse models and what they found. Ngee Kiat Chua, Hudson Coates […]

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Researchers define target and mechanism of antibacterial drug fidaxomicin (Dificid)

A team of Rutgers University and international scientists has determined the molecular target and mechanism of the antibacterial drug fidaxomicin (trade name Dificid). Fidaxomicin was approved in 2011 for treatment of the CDC “urgent threat” bacterial pathogen Clostridium difficile (C. diff) and currently is one of two front-line drugs for treatment of C. diff. Fidaxomicin also exhibits potent antibacterial activity […]

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