NIH launches large TB prevention trial for people exposed to multidrug-resistant TB

A large clinical trial to assess treatments for preventing people at high risk from developing multidrug-resistant tuberculosis (MDR-TB) has begun. The study is comparing the safety and efficacy of a new MDR-TB drug, delamanid, with the decades-old TB drug isoniazid for preventing active MDR-TB disease in children, adolescents and adults at high risk who are exposed to adult household members […]

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Large international study finds diabetes drug cuts cardiovascular and kidney problems

A clinical trial that followed more than 9,900 people in 24 countries has found that the drug dulaglutide reduced cardiovascular events and kidney problems in middle-aged and older people with Type 2 diabetes. During more than five years of follow-up, cardiovascular events like heart attacks and strokes were reduced by 12% in people taking dulaglutide compared to people taking a […]

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Study reveals large regional variations on future trends of diabetes dependent on if obesity rates are tackled

New research presented at this year’s annual meeting of the European Association for the Study of Diabetes (EASD) in Berlin looks into the rising prevalence of both obesity and type 2 diabetes (T2D) around the world and estimates the population that will likely be affected by both conditions over the coming decades. The research conducted by University College London, Steno […]

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Scientists develop new technique to heal large ulcers by reprogramming wound cells into skin cells

Plastic surgery to treat large cutaneous ulcers, including those seen in people with severe burns, bedsores or chronic diseases such as diabetes, may someday be a thing of the past. Scientists at the Salk Institute have developed a technique to directly convert the cells in an open wound into new skin cells. The approach relies on reprogramming the cells to […]

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Large number of presumed sudden cardiac deaths are not

(HealthDay)—A large percentage of deaths attributed to cardiac arrest are neither sudden nor unexpected, according to a study published recently in Circulation. Zian H. Tseng, M.D., from the University of California in San Francisco, and colleagues identified all incident deaths attributed to out-of-hospital cardiac arrest (patients between 18 and 90 years of age in San Francisco County) based on autopsy, […]

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Large US study targets prostate cancer in black men

(HealthDay)—Black men in the United States have higher rates of aggressive prostate cancer than other males. Now, a $26.5 million study is underway to figure out why. The U.S. National Institutes of Health and the Prostate Cancer Foundation have launched the study to investigate social, environmental and genetic factors behind this disparity. “No group in the world is hit harder […]

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Rheumatoid Arthritis drugs taken during pregnancy may not be linked to large infection risk in child

New research indicates that when pregnant women take certain rheumatoid arthritis (RA) drugs that may cause immunosuppression, their children do not have a marked excess risk of developing serious infections. The Arthritis & Rheumatology findings are potentially encouraging for women with RA who are or wish to become pregnant. In North America, infections are the leading cause of mortality in […]

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FDA approves CAR T therapy for large B-cell lymphoma

The U.S. Food and Drug Administration (FDA) has expanded approval for a personalized cellular therapy developed at the University of Pennsylvania’s Abramson Cancer Center, this time for the treatment of adult patients with relapsed or refractory large B-Cell lymphoma after two or more lines of systemic therapy. Today’s approval includes treatment of diffuse large B-cell lymphoma (DLBCL) – the most […]

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Study reveals large differences in drug prescriptions for newborns between NICUs

Little is known concerning how extensively drugs are prescribed to newborns in different neonatal intensive care units (NICUs). A new British Journal of Clinical Pharmacology study of nearly 1,500 newborns admitted during 12 months to four different NICUs in The Netherlands found that drug use varies widely. Cardiovascular and nervous system drugs were most often prescribed off-label in relation to […]

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