The interluekin-6 receptor (IL-6R) is the receptor that IL-6 binds to in order to initiate the body’s responses to inflammation and infection. In what is referred to as “classical signalling”, IL-6 exerts its effects by binding to IL-6R, a glycosylated type 1 membrane-bound protein of around 80 kDa. This binding is mediated by domain 2 and 3 residues on IL-6R. […]

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