inhibitors Archives - Family Medicine News

MDM2 counteracts resistance to CDK4/6 inhibitors for melanoma therapy

16.08.2019 Health Problems

A study from Vanderbilt-Ingram Cancer Center and the Department of Veterans Affairs led by Anna Vilgelm, MD, Ph.D., and Ann Richmond, Ph.D., has identified a possible second-line treatment for melanoma patients. The potential treatment would render CDK4/6 inhibitors, a class of drugs prescribed for some breast cancers, also effective against melanoma by combining the inhibitors with MDM2 compounds, which are […]

IL-1 inhibitors may reduce radiation-induced vascular damage

14.05.2019 Health Problems

Radiation therapy against cancer can increase the risk of cardiovascular disease much later in life, as the radiation causes chronic inflammation of the exposed blood vessels. In a new study published in the European Heart Journal, researchers from Karolinska Institutet in Sweden have shown that these inflammations can be treated with IL-1 inhibitors. Damage to healthy tissue is one of […]

Exploration of umbelliferone based derivatives as potent MAO inhibitors

03.01.2019 Health Problems

Monoamine oxidase (MAO) inhibitors are potential drug candidates for treating neurological disorders such as anxiety, Alzheimer’s disease and Parkinson’s disease. This review presents information about MAO inhibitory effects of the umbelliferone based derivatives. The potential antioxidant effects of the derivatives were evaluated by DPPH and H2O2 scavenging methods. The derivatives were screened for hMAO-A and hMAO-B inhibition through a series […]

Acupuncture may cut arthralgia from aromatase inhibitors

02.08.2018 Health Problems

(HealthDay)—Acupuncture may cut joint pain among postmenopausal women with early-stage breast cancer and aromatase inhibitor-related pain, according to a study published in the July 10 issue of the Journal of the American Medical Association. Dawn L. Hershman, M.D., from Columbia University in New York City, and colleagues evaluated acupuncture for reducing aromatase inhibitor-related joint pain among postmenopausal women with early-stage […]

PARP-1 may be key to effectiveness of PARP inhibitors, and now researchers can image it

27.04.2018 Health Problems

Penn Medicine researchers have used CRISPR/Cas9 gene editing technology to isolate a key genetic feature that could cause resistance to PARP inhibitors in patients with ovarian cancer—and they’ve also proven they have a way to see that feature using PET imaging. The team found PARP inhibitors—a type of targeted therapy that kills cancer cells with mutations in their DNA repair […]

New paper suggests that tumor cells may develop resistance to potential Ras inhibitors

17.04.2018 Health Problems

Researchers have long sought a treatment aimed specifically at the Ras family of genes, the most common oncogenes and those that initiate many of the most lethal tumours. However, the results of a hypothetical treatment may be far less positive than speculated, according to a manuscript published in Genes & Development by the Genomic Instability Group at the Spanish National […]