Mixed progress on drug resistance in A. baumannii infections in children

In the first national study of the prevalence of antibiotic-resistant Acinetobacter baumannii infections in children across the US, researchers from Center for Disease Dynamics, Economics, & Policy (CDDEP) in Washington, DC and Rush University in Chicago, IL examined national and regional trends of antibiotic resistance in clinical specimens over a 13-year period. While there was an overall increase between 1999 […]

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PD-L1 expression in medulloblastoma: An evaluation by subgroup

This study evaluated the expression of PD-L1 and markers of immune mediated resistance in human medulloblastoma, the most common malignant pediatric brain tumor. In cell lines, SHH MB, which are low-MYC expressing, demonstrated both constitutive and inducible expression of PD-L1 while those in Group 3/4 that expressed high levels of MYC had only inducible expression. MB expresses low levels of […]

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Formate prevents most folic acid-resistant neural tube defects in mice

Maternal folic acid supplementation has reduced the prevalence of neural tube defects, one of the most common structural malformations in people, by up to 80 percent. However, many infants are still born with a neural tube defect that appears to be resistant to folic acid supplementation. In this study, a multi-institutional research team has developed a novel folic acid-resistant neural […]

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Scientists identify two hormones that burn fat faster, prevent and reverse diabetes in mice

UCLA geneticists have created a new technique to hunt for hormones that influence how organs and tissues communicate with each other. The method enabled them to find naturally occurring molecules that play major roles in Type 2 diabetes, obesity and cardiovascular disease. In particular, they discovered: Two hormones called “notum” and “lipocalin-5” that speed up the body’s ability to burn […]

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Knowledge gaps in getting accurate blood pressure reading

Crossing your legs or even talking can have a significant impact on your blood pressure reading according to the American Heart Association, which identifies seven common errors that can lead to inaccurate blood pressure readings. May is National High Blood Pressure Education Month and the American Heart Association, the nation’s largest volunteer health organization, is bringing to light these measurement […]

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Marmosets as the canary in the coal mine for Zika

New research shows small, New World monkeys called marmosets may be an important animal model for emerging viruses with the potential for harmful effects on fetuses. Establishing animal models for emerging diseases, like Zika, is necessary for the development of vaccines, therapies and diagnostics. Results of a study published in the journal Scientific Reports showed pregnant marmosets inoculated with the […]

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