The right mouse model is crucial for Huntington’s disease drug development

Huntington’s disease (HD) is an incurable and fatal hereditary disease. Developing disease-modifying drugs to treat patients with HD depends on studying them in animal models. Scientists evaluated the mouse models used for developing new treatments for mood disorders in HD and recommended which of these models are most relevant to their studies. Their findings are published in the Journal of […]

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Scientists find excess mitochondrial iron, Huntington’s disease link

Scientists at the University of Wyoming have found that mice engineered to have Huntington’s disease (HD) have an over-accumulation of iron in their mitochondria. The research identifying a pathway for the neurodegenerative disease also has relevance to understanding related disorders such as Parkinson’s disease, Alzheimer’s and Lou Gehrig’s disease, says Jonathan Fox, a professor in UW’s Department of Veterinary Sciences. […]

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