Scientists reveal novel oncogenic driver gene in human gastrointestinal stromal tumors

Health Problems

Sarcomas—cancers that arise from transformed mesenchymal cells (a type of connective tissue)—are quite deadly. Gastrointestinal stromal tumors (GISTs) are the most common human sarcoma and are initiated by activating mutations in the KIT receptor tyrosine kinase. Micro-GISTs are a smaller variation of clinical GISTs and are found in one-third of the general population without clinical symptoms. Although the micro-GISTs and […]

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PPIs combined with oral anticoagulants reduce risk of gastrointestinal bleeding

Health Problems

A Vanderbilt University Medical Center (VUMC) study published today in JAMA shows that patients already at higher risk for gastrointestinal bleeding gain a marked protection from this risk when they take a proton pump inhibitor (PPI) in combination with an oral anticoagulant. Oral anticoagulants, which prevent blood clot formation, are among the most widely prescribed medications in the United States. […]

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