Study: Hearing develops in tandem with form and function

New research reveals a key insight into the development of hair bundles, the intricately complex assemblies in the inner ear responsible for hearing. Hair bundles are precisely arranged cellular structures deep within the spiral cavity of the inner ear. Together, they convert vibrational energy into electrical signals in the brain that translate into the sensation of hearing. Once they’re lost—whether […]

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How neural circuits form in a developing embryo

Neurons, take your places. The cells that eventually become neurons must first travel across the embryo to reach their final destinations in the nervous system. There, they blossom from undefined cells into neurons with specific roles, working together in circuits to direct an animal’s behavior. But exactly how this journey unfolds is still somewhat mysterious. “There are lots of things […]

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Researchers find targeting rare form of cystic fibrosis earlier prevents organ damage in ferrets

A team of researchers from the University of Iowa, University Medical Center Utrecht and Vertex Pharmaceuticals Incorporated, reports that earlier administration of a drug already given to patients with a rare form of cystic fibrosis can prevent organ damage—at least in ferrets. In their paper published in the journal Science Translational Medicine, the group describes their study of the impact […]

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Next-generation ALS drug silences inherited form of the disease in animal models

NIH-funded researchers delayed signs of amyotrophic lateral sclerosis (ALS) in rodents by injecting them with a second-generation drug designed to silence the gene, superoxide dismutase 1 (SOD1). The results, published in the Journal of Clinical Investigation, suggest the newer version of the drug may be effective at treating an inherited form of the disease caused by mutations in SOD1. Currently, […]

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Sunshine could hold clues on the timing for a severe form of heart attack, study says

The sun’s radiation could be a factor in seasonal patterns of a deadly type of heart attack, according to new research that tracked a “summer shift” in their occurrence across seven countries. Previous research has examined how these attacks – called ST-elevation myocardial infarctions, or STEMIs – seem to happen most often in the daytime during the colder winter months, […]

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