Resetting the epigenetic balance for cancer therapy

Though mutations in a gene called MLL3 are common across many types of cancers, their relationship to the development of the disease has been unclear. Now, a Northwestern Medicine study has identified an epigenetic imbalance that silences the expression of tumor-suppressing proteins, allowing cancerous cells to proliferate. In the study published in Nature Medicine, Northwestern investigators applied a simple molecular […]

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Robust immune responses for herpes zoster subunit vaccine

(HealthDay)—Recipients of the herpes zoster subunit vaccine (HZ/su), consisting of varicella-zoster virus glycoprotein E (gE) and AS01B Adjuvant System, develop robust immune responses, according to a study published in the June 1 issue of The Journal of Infectious Diseases. Anthony L. Cunningham, M.D., from the University of Sydney, and colleagues presented immunogenicity results from two trials involving patients aged 50 […]

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Women with pregnancy-related diabetes may be at risk for chronic kidney disease

Gestational diabetes may predispose women to early-stage kidney damage, a precursor to chronic kidney disease, according to a study by researchers at the National Institutes of Health and other institutions. The study appears in Diabetes Care. Gestational diabetes occurs only in pregnancy and results when the level of blood sugar is too high. The condition increases the risk for preterm […]

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Dilemma for cancer patients as life-saving meds are tied to vision loss

(HealthDay)—A newer type of cancer treatment may offer the chance of longer survival, but the drugs could also trigger new side effects, such as vision problems. New research reports on three cases of a potentially vision-threatening eye condition called uveal effusion that patients developed after taking cancer immunotherapy. Immunotherapy uses a person’s own immune system to fight cancer. Uveal effusion […]

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Breath test breakthrough for early diagnosis of oesophageal and gastric cancer

A breath test can successfully detect oesophageal and gastric cancer and could be used as a first-line test for patients, say researchers. In a multi-centre clinical trial of 335 patients, the breath test can identify cancer from benign diseases with 85 per cent accuracy. Unlike other methods, the test is non-invasive. The study was led by researchers at Imperial College […]

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US approves new drug for prevention of migraines

Migraine sufferers on Thursday got some relief from US regulators who approved the first of a new class of drugs for migraine prevention. The United States Food and Drug Administration said it endorsed Aimovig for prevention of migraine in adults, through monthly self-injections. Aimovig is the first in a new class of drugs that work by blocking the activity of […]

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Mass-drug administration curbs scabies for asylum seekers in the Netherlands

In a new article published in PLOS Neglected Tropical Diseases, Sofanne J. Ravensbergen of the University of Groningen, and colleagues, found that a scabies intervention program (SIP) was effective in reducing the severity of scabies when introduced to the newly arrived Eritrean and Ethiopian asylum seekers who volunteered to take part in the program. Scabies, a skin infestation caused by […]

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Automated system better identifies patients at risk for ventilator-associated pneumonia

An automated system for identifying patients at risk for complications associated with the use of mechanical ventilators provided significantly more accurate results than did traditional surveillance methods, which rely on manual recording and interpretation of individual patient data. In their paper published in Infection Control & Hospital Epidemiology, a Massachusetts General Hospital (MGH) research team report that their system—using an […]

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Keep saying yes to fish twice a week for heart health

A new scientific advisory reaffirms the American Heart Association’s recommendation to eat fish- especially those rich in Omega-3 fatty acids twice a week to help reduce the risk of heart failure, coronary heart disease, cardiac arrest and the most common type of stroke (ischemic). The advisory is published in the American Heart Association’s journal Circulation. “Since the last advisory on […]

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New study provides rationale for use of a multi-target anticancer drug in patients with malignant pleural mesothelioma

The multi-target small molecule anticancer drug nintedanib shows promising effectiveness in stopping the growth of human malignant pleural mesothelioma, a fatal thoracic tumor, in preclinical models, according to a new study published jointly by researchers in Austria, Germany and Hungary. Malignant pleural mesothelioma is a particularly aggressive tumor that occurs in the lining that covers the lungs. It typically results […]

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