Researchers criticize study calling for expansion of genetic testing for breast cancer

Researchers at the University of Cambridge have criticised a recent study calling into question guidelines on genetic testing for hereditary breast cancer. In an article published in the Journal of Clinical Oncology in December 2018 entitled “Underdiagnosis of Hereditary Breast Cancer: Are Genetic Testing Guidelines a Tool or an Obstacle?”, 27 US researchers argued for expanded genetic testing in all […]

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New target for drug intervention in Alzheimer’s disease identified

Scientists at the University of Alabama at Birmingham have identified an enzyme in the brain that may be an intriguing target for interventions against Alzheimer’s disease and other dementias. The researchers suggest that the enzyme, a serine/threonine kinase known as LIMK1, may play an important role in the degradation of dendritic spines, the connections between neurons in the brain. In […]

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NIH launches large TB prevention trial for people exposed to multidrug-resistant TB

A large clinical trial to assess treatments for preventing people at high risk from developing multidrug-resistant tuberculosis (MDR-TB) has begun. The study is comparing the safety and efficacy of a new MDR-TB drug, delamanid, with the decades-old TB drug isoniazid for preventing active MDR-TB disease in children, adolescents and adults at high risk who are exposed to adult household members […]

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Criteria for bariatric surgery should consider more than just patient’s weight

Experts at the Ohio State University Wexner Medical Center and 45 worldwide scientific and medical societies are pushing to change national guidelines that would allow more patients with the chronic diseases of obesity and diabetes to be eligible for bariatric surgery. Obesity affects almost 40 percent of the population—or about 93 million adults—in the United States, according to the Centers […]

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Exercise after surgery is important for lung cancer surgery recovery

Lung cancer patients who exercised after the surgery to remove their tumour experienced better fitness levels and strength in their leg muscles as well as less shortness of breath compared to those who did not, new research led by Curtin University has found. The research, published in the Cochrane Database of Systemic Reviews, examined whether exercise training was beneficial for […]

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Human-on-a-chip model tests cancer drug efficacy and toxicity for therapeutic index

A reconfigurable “body-on-a-chip” model could transform drug development by simultaneously measuring compound efficacy and toxicity, for both target cells and other organs, such as the heart and liver. These findings, published in Science Translational Medicine, demonstrate the ability of a body-on-a-chip model to truly revolutionize biomedical research and personalized medicine through more accurate and efficient preclinical testing without the use […]

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USPSTF addresses screening for abdominal aortic aneurysm

(HealthDay)—The U.S. Preventive Services Task Force (USPSTF) recommendations on screening for abdominal aortic aneurysm (AAA) vary with sex, age, smoking status, and family history. These recommendations form the basis of a draft recommendation statement published online June 18 by the USPSTF. Janelle M. Guirguis-Blake, M.D., from the Kaiser Permanente Center for Health Research in Portland, Oregon, and colleagues conducted a […]

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