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In people with diabetes, fat mass index, not body mass index (BMI), is associated with a higher risk of cardiovascular events, according to new research in CMAJ (Canadian Medical Association Journal). Heart disease is a major cause of death worldwide, and obesity is a major risk factor. Body mass index, a common measure of obesity, has been recently shown to […]
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The enzyme Nocturnin, which governs daily tasks such as fat metabolism and energy usage, works in an entirely different way than previously thought, reported a team of researchers at Princeton University. The newly discovered mechanism reveals the molecular link between the enzyme’s daily fluctuations and its energy-regulating role in the body, according to a study published this week in Nature […]
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Researchers have discovered differences in fat cells that could potentially identify people predisposed to metabolic diseases such as diabetes and fatty liver disease. The world-first discovery also identified ‘fast burning’ fat cells that if unlocked might help people lose weight. About 70 per cent of Australians are overweight or obese, which has been linked to metabolic disease risk. The University […]
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Fat is powering tumour growth in brain cancer, finds a new study by Cardiff University and the University of Florida. Investigating the different types of cells in glioblastoma, the research team have gained a valuable insight into what fuels slow and fast dividing cancer cells, unveiling the potential to target aggressive brain cancer more effectively. Dr. Florian Siebzehnrubl, European Cancer […]
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A new UC San Francisco study has discovered a key biological difference in how people of European and Chinese descent put on weight—a finding that could help explain why Asians often develop type 2 diabetes at a much lower body weight than Caucasians. The research, published online May 28, 2018 in the Journal of Clinical Endocrinology & Metabolism, could be […]
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An international research team in which the DZD is participating has identified a novel adipokine that favors the development of insulin resistance and systemic inflammation. In cases of severe obesity, this adipokine is secreted by the adipocytes of the abdominal fat tissue and released into the bloodstream. The new findings could contribute to the development of alternative approaches for the […]
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The same proteins that moderate nicotine dependence in the brain may be involved in regulating metabolism by acting directly on certain types of fat cells, new research from the University of Michigan Life Sciences Institute shows. Previous research by LSI research assistant professor Jun Wu and others identified a new type of fat cell in mice and humans, in addition […]
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UCLA geneticists have created a new technique to hunt for hormones that influence how organs and tissues communicate with each other. The method enabled them to find naturally occurring molecules that play major roles in Type 2 diabetes, obesity and cardiovascular disease. In particular, they discovered: Two hormones called “notum” and “lipocalin-5” that speed up the body’s ability to burn […]
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Obesity is the second-leading preventable cause of cancer and represents one of the greatest threats to global human health. But it has not been clear exactly how whole-body metabolism affects tumor formation. In particular, the molecular mechanisms by which fat cells communicate with tumor tissue remain poorly understood. Sanford Prebys Medical Discovery Institute (SBP) researchers recently addressed this question, revealing […]
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Belly fat affects the odds of women surviving kidney cancer but not men, according to a new study by researchers at Washington University School of Medicine in St. Louis. Half of female kidney cancer patients with substantial abdominal fat at the time of diagnosis died within 3 1/2 years, while more than half of women with little belly fat were […]
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