Scientists develop novel drug that could potentially treat liver cancer more effectively

A research team led by scientists from the Cancer Institute of Singapore (CSI Singapore) at the National University of Singapore (NUS) has developed a novel peptide drug called FFW that could potentially stop the development of hepatocellular carcinoma (HCC), or primary liver cancer. This landmark discovery opens the door for more effective treatment of liver cancer with less side effects. […]

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Traumatic brain injury: Discovery of two molecules could lead to new drug treatments

After 10 years of research, a Rutgers-led team of scientists has identified two molecules that protect nerve cells after a traumatic brain injury and could lead to new drug treatments. The molecules promote full recovery after traumatic brain injury (TBI) in mice, according to the study published online in Neurobiology of Disease. Traumatic brain injury is the leading cause of […]

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Next-generation ALS drug silences inherited form of the disease in animal models

NIH-funded researchers delayed signs of amyotrophic lateral sclerosis (ALS) in rodents by injecting them with a second-generation drug designed to silence the gene, superoxide dismutase 1 (SOD1). The results, published in the Journal of Clinical Investigation, suggest the newer version of the drug may be effective at treating an inherited form of the disease caused by mutations in SOD1. Currently, […]

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Enzyme identified as possible novel drug target for sickle cell disease, Thalassemia

Medical researchers have identified a key signaling protein that regulates hemoglobin production in red blood cells, offering a possible target for a future innovative drug to treat sickle cell disease (SCD). Experiments in cultured human cells reveal that blocking the protein reduces the characteristic sickling that distorts the shape of red blood cells and gives the disease its name. “We […]

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New treatment to reverse drug resistance in some cancers

University of Queensland researchers have discovered how to reverse drug resistance in skin and mouth squamous cell carcinomas. UQ Diamantina Institute Associate Professor Nicholas Saunders said squamous cell carcinomas was curable when diagnosed early but difficult to eradicate once the cancer spread. “This cancer of the skin and mouth kills approximately 1,400 Australians each year,” Dr. Saunders said. “The drugs […]

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Professor developing device to administer cancer drug

A new device under development by a nuclear engineering professor will allow doctors to dispense accurate dosages of a drug made with actinium-225, an isotope that has been shown to be effective in treating—and curing—myeloid leukemia. The device, devised by Assistant Professor Eric Lukosi and fabricated by master’s student William Gerding, is currently in production. Once it is built, it […]

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Drug treatment has profound effect on cerebral malaria in mice

A potentially new way of treating cerebral malaria has been discovered by scientists at the Universities of Manchester and Glasgow, in a study using mice. The authors found that inhibiting a complex called the inflammasome, at the same time as delivering anti-malarial drugs, reduced mortality from experimental cerebral malaria in mice. The research, published in PNAS and funded by the […]

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CDC: invasive MRSA more likely among injection drug users

(HealthDay)—Injection drug users are more than 16-fold more likely to develop invasive methicillin-resistant Staphylococcus aureus (MRSA) infections, according to research published in the June 8 issue of the U.S. Centers for Disease Control and Prevention’s Morbidity and Mortality Weekly Report. Kelly A. Jackson, M.P.H., from the CDC in Atlanta, and colleagues examined the effect of the opioid epidemic on invasive […]

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Psychedelic drug use associated with reduced partner violence in men

In a new study published in the Journal of Psychopharmacology, researchers from UBC’s Okanagan campus have discovered that men who have used psychedelic drugs in the past have a lower likelihood of engaging in violence against their intimate partners. “Although use of certain drugs like alcohol, methamphetamine or cocaine is associated with increased aggression and partner violence, use of psychedelics […]

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Common diabetes drug found safe for most diabetics with kidney disease

Results of a large-scale study suggest that the oral diabetes drug metformin is safe for most diabetics who also have chronic kidney disease (CKD). The study of more than 150,000 adults by Johns Hopkins Medicine investigators found that metformin’s association with the development of a life-threatening condition called lactic acidosis was seen only among patients with severely decreased kidney function. […]

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