Inflammation inhibitor delivered directly to kidneys reverses course of destructive nephritis

Using a manmade version of a human antibody to directly deliver a drug that inhibits a powerful driver of inflammation, can reverse a disease course that often leads to kidney failure and dialysis, investigators report. They have additionally found that it’s the powerhouses of kidney cells, called mitochondria, that are particularly impacted by the acute or chronic inflammation called nephritis, […]

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Older age tied to poorer course of major depressive disorder

(HealthDay)—Older age is associated with poorer course of major depressive disorder (MDD), according to a study published online June 7 in The Lancet Psychiatry. Roxanne Schaakxs, Ph.D., from VU University Medical Center in Amsterdam, and colleagues obtained data for 1,042 participants with MDD at baseline, who had data available at baseline and two-year follow-up. The primary outcome was the two-year […]

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Seven-day antibiotic course delivers similar outcomes to 14-days for Gram-negative bacteraemia

A seven-day course of antibiotic treatment for Gram-negative bacteraemia (GNB), a serious infection that occurs when bacteria get into the bloodstream, was shown to offer similar patient outcomes as a 14-day course, according to research presented at the 28th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID). Researchers assessed several primary outcomes, including mortality and whether a patient was […]

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Oral sirolimus alters the course of DIPNECH syndrome in three patients

Sirolimus, which is used to prevent rejection after kidney transplants, has been used to successfully treat three cases of a rare disorder called diffuse idiopathic pulmonary neuroendocrine cell hyperplasia, or DIPNECH syndrome. The syndrome is so rare that there are no clinical recommendations to guide care and, therefore, no proven therapies. The brief case report is published in Annals of […]

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