A common insulin signaling pathway across cancer and diabetes

An oncology researcher has made an unexpected contribution to the understanding of type 2 diabetes. In results published in Science Advances, Patrick Hu, M.D., associate professor of medicine at Vanderbilt University Medical Center, found a protein that modulates a signaling pathway often targeted by cancer therapies is also required for insulin biogenesis. Hu and colleagues showed a protein controlling the […]

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Common brain disorders accelerate brain aging

Common brain disorders seem to be associated with accelerated aging of the brain, according to a new international study using machine learning models to analyse structural brain MRI data from more than 45,000 individuals. The researchers discovered that people with memory disorders, multiple sclerosis (MS) and schizophrenia, among other conditions, have an older-looking brain than it really is; however, there […]

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Psychotic experiences are quite common even among people who don’t have a mental health condition

Have you ever seen or heard something that turned out not to exist? Or have you ever thought something was happening that no one else noticed—perhaps thinking you were being followed, or that something was trying to communicate with you? If so, you may have had a psychotic experience. The good news is, you’re not alone. Psychosis, also called a […]

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Scientists uncover novel strategy to target common type of cancer

Researchers have identified a protein critical for the survival of a particular type of tumor cell, according to a study published today in eLife. The findings, originally posted on bioRxiv, suggest that targeting a protein called Werner syndrome helicase (WRN) could represent a novel opportunity for treating a subgroup of cancer patients with microsatellite instability-high (MSI-H) tumors. MSI is a […]

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Common heart condition linked to sudden death

A University of Adelaide-led team of researchers has found a link between sudden cardiac death (when the heart suddenly stops beating) and a common heart condition known as mitral valve prolapse that affects around 12 in every 1000 people worldwide. In a paper, published in Heart, researchers analysed more than 7600 studies and found that 12% of victims of sudden […]

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Prosthetic valve mismatches common in transcatheter valve replacement, ups risk of death

In the largest multi-institutional study to date, led by researchers from Penn Medicine, the team found that among patients who underwent a transcatheter aortic valve replacement (TAVR), a high number experienced severe and moderate cases of prosthesis-patient mismatch (PPM)—meaning the implanted heart valve is too small for the patient which can lead to inadequate blood flow. The team also found […]

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Repeat CT common in peds traumatic epidural hematoma

(HealthDay)—For children with traumatic epidural hematomas (EDHs), repeated computed tomography (CT) imaging is common, but rarely impacts management, according to a study published in the September issue of Pediatrics. Brian F. Flaherty, M.D., from the University of Utah in Salt Lake City, and colleagues conducted a retrospective cohort study involving 184 subjects aged 0 to 18 years who had a […]

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Co-infection with vaginitis and sexually transmitted infection may be more common than previously acknowledged

New data suggest that women testing positive for vaginitis or bacterial vaginosis may be at higher risk than normal for a sexually transmitted infection. A study published in the most recent issue of Clinical Infectious Disease by Barbara Van Der Pol, Ph.D., associate professor in the University of Alabama at Birmingham Division of Infectious Diseases, found that women who test […]

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