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Plastic surgery to treat large cutaneous ulcers, including those seen in people with severe burns, bedsores or chronic diseases such as diabetes, may someday be a thing of the past. Scientists at the Salk Institute have developed a technique to directly convert the cells in an open wound into new skin cells. The approach relies on reprogramming the cells to […]
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What’s the secret to aging well? University of Minnesota Medical School researchers have answered it- on a cellular level. Aging starts in our cells, and those aging cells can hasten cellular senescence, leading to tissue dysfunction and related health impacts. New research involving University of Minnesota Medical School faculty Paul D. Robbins and Laura J. Niedernhofer, recently published in Nature […]
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Johns Hopkins Medicine scientists say they have found new evidence in lab-grown mouse brain cells, called astrocytes, that one root of Alzheimer’s disease may be a simple imbalance in acid-alkaline—or pH—chemistry inside endosomes, the nutrient and chemical cargo shuttles in cells. Astrocytes work to clear so-called amyloid beta proteins from the spaces between neurons, but decades of evidence has shown […]
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In an article published July 17, 2018 by Nature Communications, a highly collaborative team of researchers at the Medical University of South Carolina (MUSC) and Ohio State University report that normal breast cells can prevent successful radiation treatment of breast cancer due to dysregulation between tumor suppressors and oncogenes. Tumor suppressors act like brakes that stop cells from undergoing uncontrolled […]
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Multiple pregnancies might make women’s cells age more quickly, a new Northwestern University study suggests. Led by Calen Ryan and Christopher Kuzawa of Northwestern and Dan Eisenberg at the University of Washington, the research could help explain why women with many children tend to show signs of accelerated aging. The findings, published this week in Scientific Reports, were reached by […]
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Pancreatic cancer often spreads, forming metastases in the liver or lungs. The prognosis is better for patients with metastases in the lungs. However, the cancer cells’ ability to alter their characteristics and shape influences which organ is affected, as a research team at the Technical University of Munich (TUM) has discovered. Cells in a tissue or tumor establish contacts with […]
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The advent and advancement of T cell therapy, especially chimeric antigen receptor (CAR)-modified T cells, has demonstrated therapeutic potential in treating previously treatment-resistant tumors. However, few CAR targets are absolutely tumor-specific, resulting in “on-target, off-tumor” toxicities that can be severe. Researchers in the Center for Cell and Gene Therapy at Baylor College of Medicine, Texas Children’s Hospital and Houston Methodist […]
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Monash University researchers have restored movement and regenerated nerves using stem cells in zebra fish where the spinal cord is severely damaged. The research, presented at the International Society for Stem Cell Research conference in Melbourne this week, raises the possibility that these same stem cells could be triggered in human patients who have suffered paralysing damage to their nervous […]
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A surprising form of cell-to-cell communication in glioblastoma promotes global changes in recipient cells, including aggressiveness, motility, and resistance to radiation or chemotherapy. Paradoxically, the sending cells in this signaling are glioblastoma cells that are undergoing programmed cell death, or apoptosis, according to research by a team at institutes in the United States, Russia and South Korea. The dying cancer […]
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A research team at Massachusetts Eye and Ear has shown that microglia, the primary immune cells of the brain and retina, play a protective role in response to retinal detachment. Retinal detachment and subsequent degeneration of the retina can lead to progressive visual decline due to photoreceptor cell death, the major light-sensing cell in the eye. In a report published […]
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