Why screen time can disrupt sleep—scientists uncover how certain retinal cells respond to artificial illumination

For most, the time spent staring at screens—on computers, phones, iPads—constitutes many hours and can often disrupt sleep. Now, Salk Institute researchers have pinpointed how certain cells in the eye process ambient light and reset our internal clocks, the daily cycles of physiological processes known as the circadian rhythm. When these cells are exposed to artificial light late into the […]

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Proteins cooperate to break up energy structures in oxygen starved heart cells

During a heart attack, the supply of oxygen to heart cells is decreased. This reduced oxygen level, called hypoxia, causes the cell’s powerhouses, the mitochondria, to fragment, impairing cell function and leading to heart failure. Until now, few details have been known about how this process occurs. Researchers at the National Institute for Physiological Sciences, Japan, have revealed how filamin […]

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Immune cells trigger OCD-like behaviour in multiple sclerosis, study finds

A class of cells that defends the body against invaders also triggers obsessive-compulsive behaviour that appears in autoimmune disorders such as multiple sclerosis (MS), a new study from the Indian Institute of Science (IISc) has found. Autoimmune disorders, in which the body’s immune system goes rogue and attacks healthy cells, are difficult to treat. MS, for example, is a debilitating […]

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Cells in ‘little brain’ have distinctive metabolic needs

Cells’ metabolic needs are not uniform across the brain, researchers have learned. “Knocking out” an enzyme that regulates mitochondria, cells’ miniature power plants, specifically blocks the development of the mouse cerebellum more than the rest of the brain. The results are scheduled for publication in Science Advances. “This finding will be tremendously helpful in understanding the molecular mechanisms underlying developmental […]

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Human hair cells from a test tube

Researchers from the University of Bern and Bern University Hospital have managed for the first time to differentiate human inner ear cells in a laboratory from somatic progenitors and to investigate their origin. This will make it possible to develop new treatment methods for hearing impairment in the future. About 5% of the world population suffers from hearing impairment. Disabling […]

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Can we teach heart cells to grow up?

Scientists around the world have been trying to replace damaged heart tissue using lab-made heart-muscle cells (cardiomyocytes), either injecting them into the heart or applying patches laced with the cells. But results to date have been underwhelming. “If you make cardiomyocytes in a dish from pluripotent stem cells, they will engraft in the heart and form muscle,” says William Pu, MD, […]

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