Study results may lead to improved diagnostics for breast cancer

A study in Molecular Oncology indicates that examining the protein and RNA in leftover materials from routine diagnostic tests for breast cancer may lead to more accurate diagnoses. Using samples from fine needle aspiration from 25 patients with breast cancer and 33 patients with benign lesions, investigators found that such a strategy could distinguish all cancer patient samples from all […]

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‘Slow but sure’ progress toward less toxic tools to fight cancer

John Ryan is just one of the miracles to emerge from the Johns Hopkins cancer unit in Baltimore. An immunotherapy treatment—highly effective in a minority of patients—saved his life after a lung cancer diagnosis. The retired military nuclear reactor specialist will celebrate his 74th birthday in July, and his battle with cancer illustrates the promises and failures of immunotherapy, a […]

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Computer algorithm maps cancer resistance to drugs, therapy

New methods of studying the evolution of treatment resistance in head and neck cancer are being developed by researchers at the Johns Hopkins Kimmel Cancer Center. The scientists wanted to examine how cancers acquire resistance to treatment over time and whether those changes could be modeled computationally to determine patient-specific timelines of resistance. The research was published by Genome Medicine […]

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Men and women have different genetic risk factors for developing brain cancer

Glioma is the most common type of primary malignant brain tumor in the United States; glioblastoma being the most common type of glioma in adults. While sex differences in the incidence and survival rates of glioma were known, researchers had not investigated whether genetic differences based on sex could cast light on potential differences in the risk profile of glioma […]

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Professor developing device to administer cancer drug

A new device under development by a nuclear engineering professor will allow doctors to dispense accurate dosages of a drug made with actinium-225, an isotope that has been shown to be effective in treating—and curing—myeloid leukemia. The device, devised by Assistant Professor Eric Lukosi and fabricated by master’s student William Gerding, is currently in production. Once it is built, it […]

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South Africa’s battle to resuscitate cancer care

South African electrician Phiwankosi Mkhize was diagnosed with lung cancer in May last year and told by the hospital to come back for a scan in 15 months. But after just 12 months he died, before having the chance to receive treatment. The 66-year-old’s fate is far from unique in southeastern KwaZulu-Natal province, the country’s second most populous. Hundreds of […]

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Dying cancer cells make remaining glioblastoma cells more aggressive and therapy-resistant

A surprising form of cell-to-cell communication in glioblastoma promotes global changes in recipient cells, including aggressiveness, motility, and resistance to radiation or chemotherapy. Paradoxically, the sending cells in this signaling are glioblastoma cells that are undergoing programmed cell death, or apoptosis, according to research by a team at institutes in the United States, Russia and South Korea. The dying cancer […]

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