New lab study reveals how breast cancer drug can accelerate cancer cell growth

The breast cancer drug lapatinib which is designed to shrink tumours can sometimes cause them to grow in the lab, according to a new study published in eLife. By understanding the molecular basis of this phenomenon, scientists hope that their findings will lead to safer treatment decision-making and drug design in the future. Lapatinib is used in combination with other […]

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Antibody ‘cocktail’ can prevent Zika infection but is not effective for treatment of fetuses

A “cocktail” of monoclonal antibodies that can prevent Zika virus (ZIKV) infection in primates was not effective for treatment of fetuses, according to a new collaborative study led by a University of Miami Miller School of Medicine research team. “We observed that ZIKV isolated from pregnant women in Rio de Janeiro also causes fetal infection in pregnant macaques. Unfortunately, we […]

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PARP-1 may be key to effectiveness of PARP inhibitors, and now researchers can image it

Penn Medicine researchers have used CRISPR/Cas9 gene editing technology to isolate a key genetic feature that could cause resistance to PARP inhibitors in patients with ovarian cancer—and they’ve also proven they have a way to see that feature using PET imaging. The team found PARP inhibitors—a type of targeted therapy that kills cancer cells with mutations in their DNA repair […]

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Research finds new mechanism that can cause the spread of deadly infection

Scientists at the University of Birmingham have discovered a unique mechanism that drives the spread of a deadly infection. Cptococcosirys is a rare and deadly fungal infection that affects the lung and brain and usually only occurs in people with impaired immunity. However, one strain of the fungus – known as the Pacific Northwest strain of Cryptococcus gattii – has […]

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Can a brain injury change who you are?

Who we are, and what makes us “us” has been the topic of much debate throughout history. At the individual level, the ingredients for the unique essence of a person consist mostly of personality concepts. Things like kindness, warmth, hostility and selfishness. Deeper than this, however, is how we react to the world around us, respond socially, our moral reasoning, […]

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Protein can slow intestinal tumor growth

A new mechanism for regulating stem cells in the intestine of fruit flies has been discovered by researchers at Stockholm University. In addition, it was discovered that a certain protein can slow the growth of tumours in intestinal tissue. A better understanding of these mechanisms can teach us more about how diseases in human intestines occur, as well as contribute […]

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Can early counselling prevent post traumatic stress induced by heart attacks?

A randomized controlled trial published in the current issue of Psychotherapy and Psychosomatics indicates that early counseling has a very limited role in preventing distress after heart attacks. Acute coronary syndrome (ACS)-induced posttraumatic stress disorder (PTSD) and clinically significant PTSD symptoms are found in 4 and 12 percent of patients, respectively. Hence, this randomized-controlled trial aimed to test whether early […]

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Can fish oil supplementation attenuate stress symptoms in high risk jobs?

A study published in the current issue of Psychotherapy and Psychosomatics suggests a role for fish-oil supplementation in workers who perform very stressful jobs. There is growing attention being paid to fish oil as one of the promising supplementations to improve symptoms of posttraumatic stress disorder (PTSD) by facilitating hippocampal neurogenesis and clearance of fear memory. The purpose of this […]

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