Sepsis—an extreme response to infection—can cause damage to multiple organ systems when it triggers an uncontrolled inflammatory response. C. Henrique Serezani, Ph.D., and colleagues are seeking molecular “brakes” that will dampen sepsis-induced inflammation and prevent organ damage. They investigated a role for an enzyme called PTEN, a lipid and protein phosphatase that regulates various pathways of the immune response. They […]

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