Algorithm based on response, biology guides neuroblastoma therapy

Health Problems

(HealthDay)—Use of a response- and biology-based treatment algorithm for intermediate-risk neuroblastoma is associated with excellent survival and reduces treatment for some patients, according to a study published online Aug. 6 in the Journal of Clinical Oncology. Clare J. Twist, M.D., from the Roswell Park Cancer Institute in Buffalo, New York, and colleagues enrolled 404 evaluable patients between 2007 and 2011 […]

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New method classifies brain cells based on electrical signals

Health Problems

For decades, neuroscientists have relied on a technique for reading out electrical “spikes” of brain activity in live, behaving subjects that tells them very little about the types of cells they are monitoring. In a new study, researchers at the University of Tuebingen and MIT’s Picower Institute for Learning and Memory demonstrate a way to increase their insight by distinguishing […]

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Exploration of umbelliferone based derivatives as potent MAO inhibitors

Health Problems

Monoamine oxidase (MAO) inhibitors are potential drug candidates for treating neurological disorders such as anxiety, Alzheimer’s disease and Parkinson’s disease. This review presents information about MAO inhibitory effects of the umbelliferone based derivatives. The potential antioxidant effects of the derivatives were evaluated by DPPH and H2O2 scavenging methods. The derivatives were screened for hMAO-A and hMAO-B inhibition through a series […]

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Concussion-related biomarkers vary based on sex, race

Health Problems

(HealthDay)—Concussion-related serum biomarkers vary by sex and race, which may complicate their interpretation, according to three studies published online Nov. 7 in Neurology. Breton M. Asken, from the University of Florida in Gainesville, and colleagues conducted an observational cohort study and measured serum concentrations of biomarkers in 415 nonconcussed collegiate athletes without recent exposure to head impacts to describe the […]

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