Rapid tissue donation program offers feasible approach to improve research

Precision medicine with targeted therapies has led to improved treatment options and patient outcomes. These approaches were developed by studying tumors grown in laboratories and patient samples obtained before and during their treatment. However, there is often a limited supply of patient samples to adequately study, and the samples that exist do not always tell the complete genetic story of […]

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New approach to shutting down breast cancer recurrence shows promise in mice

A new approach to treat advanced breast cancer shuts down the growth of cells that become resistant to standard hormone therapy, according to Duke Cancer Institute animal studies. The research, which is likely to be tested in clinical trials within the year, identified and targeted vulnerabilities that appear in nearly all estrogen-positive breast cancers that develop resistance to current treatments. […]

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Tackling zinc deficiency with a new approach to urine testing

Imperial College London researchers have developed a new urine test that looks to chemical fingerprints for more precise zinc testing. This new approach, outlined in a new paper published in Metallomics, could provide more specific tests to warn of zinc deficiency—particularly in developing countries. Caroline Brogan spoke to lead author Dr. Rebekah Moore, from Imperial’s Department of Earth Science and […]

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Novel approach leads to potential sepsis prevention in burn patients

Immediately following severe burns, bacteria reach the wound from different sources, including the patient’s skin, gastrointestinal tract, respiratory tracts and health care-related human contact. Within the wound, bacteria multiply, establish an infection and move from the infected burn wound into the bloodstream, causing serious complications like sepsis, multiple-organ failure and death. In modern burn units, more than 50% of deaths […]

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Injectable ‘bone spackling’: A cell therapy approach to heal complex fractures

Large, complex bone wounds are hard for doctors and patients alike to contend with. They often require grafts and multiple surgeries. Jan Stegemann, a University of Michigan professor of biomedical engineering, is reprogramming adult cells from bone marrow so that they can be injected directly into a wound and grow into bone. The marrow-derived cells are known as progenitor cells, […]

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New therapy approach points to potential treatment of liver cancer patients with hepatitis B virus infection

Researchers from Duke-NUS Medical School, Singapore General Hospital (SGH) and Lion TCR have demonstrated that they were able to engineer HBV-specific T cells, a type of immune cells found in the body, to treat Hepatocellular carcinoma (HCC), a commonly occurring liver cancer. The treatment was also individualised, as T cells that were engineered were specific to the patients. The approach […]

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Encouraging more health workers to have flu jab needs new approach that connects on an emotional level

Persuading more health workers to have the flu jab to protect themselves and their patients cannot be done through facts and statistics alone, new research by a leading behavioural scientist from Kingston University has revealed. Instead it demands a new approach that connects with people emotionally to sustain immunisation rates at effective levels. Nearly one third of nurses, GPs and […]

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Experts call for a targeted approach to cancer prevention

Policymakers around the world should consider introducing more targeted early interventions in a bid to tackle cancer, according to experts at the University of Stirling. A new paper – published in the International Journal of Healthcare Policy – analysed data from 162 countries to examine the relationship between economic growth and cancer incidence. Dr. Bryan McIntosh, of the Faculty of […]

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New approach could jumpstart breathing after spinal cord injury

A research team at the Krembil Research Institute in Toronto has developed an innovative strategy that could help to restore breathing following traumatic spinal cord injury. The team, led by principal investigator Dr. Michael Fehlings—a neurosurgeon/neuroscientist, specialist in spinal cord injury and senior scientist at UHN—published its findings today in the journal Nature in a paper titled “Cervical excitatory neurons […]

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