How an AI solution can design new tuberculosis drug regimens

With a shortage of new tuberculosis drugs in the pipeline, a software tool from the University of Michigan can predict how current drugs—including unlikely candidates—can be combined in new ways to create more effective treatments. “This could replace our traditional trial-and-error system for drug development that is comparatively slow and expensive,” said Sriram Chandrasekaran, U-M assistant professor of biomedical engineering, […]

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Probing the role of an inflammation resolution sensor in obesity and heart failure

After heart attack injury, several fatty-acid-derived bioactive molecules—including one called resolvin D1—play an essential signaling role to safely clear inflammation and help repair heart muscle. The mechanism of how this resolution occurs is not well-understood. There is a receptor on the surface of many immune cells called ALX/FRP2, and in models of atherosclerosis, ALX/FPR2 is known to act as a […]

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When is a child an adult?

When does childhood end? That’s the question international researchers are asking as they chart age cut-offs for paediatric services around the world. Adolescent Health Professor at the Murdoch Children’s Research Institute and the University of Melbourne Susan Sawyer says previous research has found that global health systems do not meet adolescents’ needs. “Yet pediatricians are well placed to provide age-appropriate […]

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An innovative new diagnostic for Lyme disease

When researchers examined the mitochondrial DNA of Ötzi, a man entombed in ice high in the Tyrolean Alps some 5,300 years ago, they made a startling discovery. Secreted within the tangles of the ice man’s genetic code was evidence he’d been infected with a bacterial pathogen, Borrelia burgdorferi. Ötzi is the first known case of Lyme disease. Today, Lyme disease […]

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When does trash talking work? An expert discusses her unusual research

Karen C.P. McDermott recently completed a study on trash talk, the taunts or boasts meant to intimidate or distract an opponent. Her study was one of the first to statistically model how trash talking during a competition can influence performance. What inspired you to study trash talk? Karen C.P. McDermott: In early 2014, I watched Seattle Seahawks cornerback Richard Sherman […]

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New study reveals an unexpected survival mechanism of a subset of cancer cells

Embedded at the ends of chromosomes are structures called telomeres, which in normal cells become shorter as cells divide. Progressive shortening triggers cell proliferation arrest or death. Cancer cells adopt different strategies to overcome this control mechanism that keeps track of the number of times that a cell has divided. One of these strategies is the alternative lengthening of telomeres […]

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Jon Voight Gives an Update on Angelina Jolie and Brad Pitt’s Children

Proud grandparent! Jon Voight gave an update on his daughter Angelina Jolie’s six children, who she shares with her estranged husband, Brad Pitt. “The kids are great. They’re growing up,” the Ray Donovan actor, 80, told Us Weekly exclusively at the International Champions of Jewish Values Gala on Thursday, March 28. “They’re doing very well.” Voight added: “It’s just amazing […]

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