Family Medicine News

Mouse study identifies new target for human accelerated aging syndrome

27.04.2018 Health Problems

Scientists from the University of Cambridge have identified a potential therapeutic target in the devastating genetic disease Hutchinson-Gilford Progeria Syndrome (HGPS), which is characterised by premature ageing. In a paper published today in Nature Communications, scientists provide preclinical data showing that chemical inhibition or genetic deregulation of the enzyme N-acetyltransferase 10 (NAT10) leads to significant health and lifespan gains in […]

Multiple anesthesia exposures affect learning and attention

27.04.2018 Kids Health

(HealthDay)—Children with multiple exposures to anesthesia before age 3 are more likely to develop adverse outcomes related to learning and attention, according to a recent study published in Anesthesiology. Danqing Hu, M.D., from the Mayo Clinic in Rochester, Minn., and colleagues retrospectively identified a cohort of children born between 1996 and 2000. Propensity matching selected children based on exposure or […]

Antibody ‘cocktail’ can prevent Zika infection but is not effective for treatment of fetuses

27.04.2018 Health Problems

A “cocktail” of monoclonal antibodies that can prevent Zika virus (ZIKV) infection in primates was not effective for treatment of fetuses, according to a new collaborative study led by a University of Miami Miller School of Medicine research team. “We observed that ZIKV isolated from pregnant women in Rio de Janeiro also causes fetal infection in pregnant macaques. Unfortunately, we […]

Three-minute version of brain stimulation therapy effective for hard-to-treat depression

27.04.2018 Health Problems

In the largest study of its kind, a three-minute version of a brain stimulation treatment was shown to be just as effective as the standard 37-minute version for hard-to-treat depression. These results were published in a new Canadian study in The Lancet co-led by the Centre for Addiction and Mental Health (CAMH) and the University Health Network’s Krembil Research Institute, […]

PARP-1 may be key to effectiveness of PARP inhibitors, and now researchers can image it

27.04.2018 Health Problems

Penn Medicine researchers have used CRISPR/Cas9 gene editing technology to isolate a key genetic feature that could cause resistance to PARP inhibitors in patients with ovarian cancer—and they’ve also proven they have a way to see that feature using PET imaging. The team found PARP inhibitors—a type of targeted therapy that kills cancer cells with mutations in their DNA repair […]

Largest-ever study of thyroid cancer genetics finds new mutations, suggests immunotherapy

27.04.2018 Health Problems

University of Colorado Cancer Center researchers recently completed the largest-ever study of thyroid cancer genetics, mining the data of 583 patient samples of advanced differentiated thyroid cancer and 196 anaplastic thyroid cancers. In addition to identification of specific genes that may drive these cancers and thus provide attractive targets for treatment, the researchers found that in several samples of advanced […]

Noninvasive brain tumor biopsy on the horizon

26.04.2018 Health Problems

Taking a biopsy of a brain tumor is a complicated and invasive surgical process, but a team of researchers at Washington University in St. Louis is developing a way that allows them to detect tumor biomarkers through a simple blood test. Hong Chen, a biomedical engineer, and Eric C. Leuthardt, MD, a neurosurgeon, led a team of engineers, physicians and […]

Noninvasive spinal stimulation method enables paralyzed people to regain use of hands, study finds

26.04.2018 Health Problems

The ability to perform simple daily tasks can make a big difference in people’s lives, especially for those with spinal cord injuries. A UCLA-led team of scientists reports that six people with severe spinal cord injuries—three of them completely paralyzed—have regained use of their hands and fingers for the first time in years after undergoing a nonsurgical, noninvasive spinal stimulation […]

Common class of drugs linked to dementia even when taken 20 years before diagnosis

26.04.2018 Health Problems

The largest and most detailed study of the long-term impact of anticholinergic drugs, a class of drugs commonly prescribed in the United States and United Kingdom as antidepressants and incontinence medications, has found that their use is associated with increased risk of dementia, even when taken 20 years before diagnosis of cognitive impairment. An international research team from the US, […]

Preventive use of common antibiotic reduces child mortality in sub-Saharan Africa

26.04.2018 Health Problems

Treating young children in Sub-Saharan Africa with azithromycin, a safe, inexpensive, and widely used antibiotic, significantly reduced deaths of children under five in a large randomized trial led by scientists at UC San Francisco. The finding could help speed progress toward the United Nations’ goal of ending preventable child deaths by 2030. Researchers randomized 1,533 communities in Niger, Malawi, and […]

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