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From burning your palm on a hot pan handle to memorizing the name of a new acquaintance, “anytime you experience something, your neurons are active,” says Kelsey Tyssowski, a graduate student in genetics at Harvard Medical School. Different experiences stimulate different patterns of activity in brain cells. Researchers want to track these activity patterns to better understand how the brain […]
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The deadly yellow fever virus has the potential to spread into cities around the world where it previously hasn’t been seen, according to a new study led by St. Michael’s Hospital. Researchers led by Dr. Kamran Khan of St. Michael’s have mapped the worldwide pathways through which yellow fever virus could spread by analyzing global patterns of airline travellers, the […]
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Scientists from the University of Cambridge have identified a potential therapeutic target in the devastating genetic disease Hutchinson-Gilford Progeria Syndrome (HGPS), which is characterised by premature ageing. In a paper published today in Nature Communications, scientists provide preclinical data showing that chemical inhibition or genetic deregulation of the enzyme N-acetyltransferase 10 (NAT10) leads to significant health and lifespan gains in […]
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(HealthDay)—Children with multiple exposures to anesthesia before age 3 are more likely to develop adverse outcomes related to learning and attention, according to a recent study published in Anesthesiology. Danqing Hu, M.D., from the Mayo Clinic in Rochester, Minn., and colleagues retrospectively identified a cohort of children born between 1996 and 2000. Propensity matching selected children based on exposure or […]
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A “cocktail” of monoclonal antibodies that can prevent Zika virus (ZIKV) infection in primates was not effective for treatment of fetuses, according to a new collaborative study led by a University of Miami Miller School of Medicine research team. “We observed that ZIKV isolated from pregnant women in Rio de Janeiro also causes fetal infection in pregnant macaques. Unfortunately, we […]
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In the largest study of its kind, a three-minute version of a brain stimulation treatment was shown to be just as effective as the standard 37-minute version for hard-to-treat depression. These results were published in a new Canadian study in The Lancet co-led by the Centre for Addiction and Mental Health (CAMH) and the University Health Network’s Krembil Research Institute, […]
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Penn Medicine researchers have used CRISPR/Cas9 gene editing technology to isolate a key genetic feature that could cause resistance to PARP inhibitors in patients with ovarian cancer—and they’ve also proven they have a way to see that feature using PET imaging. The team found PARP inhibitors—a type of targeted therapy that kills cancer cells with mutations in their DNA repair […]
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University of Colorado Cancer Center researchers recently completed the largest-ever study of thyroid cancer genetics, mining the data of 583 patient samples of advanced differentiated thyroid cancer and 196 anaplastic thyroid cancers. In addition to identification of specific genes that may drive these cancers and thus provide attractive targets for treatment, the researchers found that in several samples of advanced […]
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Taking a biopsy of a brain tumor is a complicated and invasive surgical process, but a team of researchers at Washington University in St. Louis is developing a way that allows them to detect tumor biomarkers through a simple blood test. Hong Chen, a biomedical engineer, and Eric C. Leuthardt, MD, a neurosurgeon, led a team of engineers, physicians and […]
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The ability to perform simple daily tasks can make a big difference in people’s lives, especially for those with spinal cord injuries. A UCLA-led team of scientists reports that six people with severe spinal cord injuries—three of them completely paralyzed—have regained use of their hands and fingers for the first time in years after undergoing a nonsurgical, noninvasive spinal stimulation […]
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