Large number of presumed sudden cardiac deaths are not

(HealthDay)—A large percentage of deaths attributed to cardiac arrest are neither sudden nor unexpected, according to a study published recently in Circulation. Zian H. Tseng, M.D., from the University of California in San Francisco, and colleagues identified all incident deaths attributed to out-of-hospital cardiac arrest (patients between 18 and 90 years of age in San Francisco County) based on autopsy, […]

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First in-depth profile of CAR T-cell signals suggests how to improve immunotherapy

CAR T-cell therapy, which reprograms immune cells to fight cancer, has shown great promise in people with some blood cancers who have not responded to other treatments. But until now, the underlying biological pathways enabling anti-cancer responses have not been thoroughly examined. Understanding these pathways is important for designing future generations of CAR T-cell therapies, including reducing side effects, preventing […]

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New compound advances into Phase 1 trial for pancreatic cancer

A compound discovered at Sanford Burnham Prebys Medical Discovery Institute (SBP) has advanced into a Phase 1 trial for metastatic pancreatic cancer. Called CEND-1 (scientifically known as iRGD), the compound was exclusively licensed in 2015 to a private company, DrugCendR Inc. The drug candidate was discovered in the laboratory of Erkki Ruoslahti, M.D., Ph.D., distinguished professor at SBP and founder, […]

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AAP outlines appropriate pediatric nephrology testing

(HealthDay)—As part of the Choosing Wisely campaign, a list of specific nephrology tests and procedures that are commonly ordered but not always needed when treating children for kidney-related conditions has been released by the American Academy of Pediatrics (AAP). After careful review and analysis, five evidence-based recommendations were developed for tests and procedures that physicians and patients should question. According […]

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Good news, bad news in U.S. breastfeeding report

(HealthDay)—Most new mothers in the United States start out breastfeeding, but many stop sooner than recommended, a new federal government report says. Of the nearly 4 million babies born in 2015, about 83 percent started out breastfeeding, but fewer than 36 percent were still breastfeeding at 12 months, according to the U.S. Centers for Disease Control and Prevention. Nearly 6 […]

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