Exploration of umbelliferone based derivatives as potent MAO inhibitors

Monoamine oxidase (MAO) inhibitors are potential drug candidates for treating neurological disorders such as anxiety, Alzheimer’s disease and Parkinson’s disease. This review presents information about MAO inhibitory effects of the umbelliferone based derivatives. The potential antioxidant effects of the derivatives were evaluated by DPPH and H2O2 scavenging methods. The derivatives were screened for hMAO-A and hMAO-B inhibition through a series […]

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Tiny, implantable device uses light to treat bladder problems

A team of neuroscientists and engineers has developed a tiny, implantable device that has potential to help people with bladder problems bypass the need for medication or electronic stimulators. The team—from Washington University School of Medicine in St. Louis, the University of Illinois at Urbana-Champaign, and the Feinberg School of Medicine at Northwestern University in Chicago—created a soft, implantable device […]

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Engineers create delicate sensor to monitor heart cells with minimal disruption

For the first time, engineers have demonstrated an electronic device to monitor beating heart cells without affecting their behavior. A collaboration between the University of Tokyo, Tokyo Women’s Medical University and RIKEN in Japan produced a functional sample of heart cells with a soft nanomesh sensor in direct contact with the tissue. This device could aid study of other cells, […]

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Heart patients need kindness as much as medical intervention

Heart attack patients can suffer substantial emotional trauma once the medics have finished making their bodies better, according to new research. The emotional whiplash can range from phobia about moving in case their heart rate rises, to difficulty accepting a new identity as someone with a serious health condition. The study found emotional trauma following a heart attack was more […]

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Patients now living a median 6.8 years after stage IV ALK+ lung cancer diagnosis

According to the National Cancer Institute, patients diagnosed with non-small cell lung cancer (NSCLC) between the years 1995 and 2001 had 15 percent chance of being alive 5 years later. For patients with stage IV disease, describing cancer that has spread to distant sites beyond the original tumor, that statistic drops to 2 percent. Now a University of Colorado Cancer […]

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Breaking down AGEs: Insight into how lifestyle drives ER-positive breast cancer

Poor diet and lack of exercise are associated with cancer development, but the underlying biology is not well understood. Advanced glycation end products (AGEs) could offer a biological link to help us understand how certain lifestyle behaviors increase cancer risk or lessen the likelihood that an anti-cancer therapy will be effective. AGE accumulation is the natural and unavoidable result of […]

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FDA approves drugs for treatment of two rare blood diseases

(HealthDay)—Two drugs have been approved by the U.S. Food and Drug Administration for the treatment of rare blood diseases, the agency announced Friday. Elzonris (tagraxofusp-erzs) infusion was granted the first approval for the treatment of blastic plasmacytoid dendritic cell neoplasm (BPDCN) in adults and children aged 2 years and older. Researchers investigated the efficacy of Elzonris in two patient cohorts […]

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AR101

BRISBANE, Calif.–(BUSINESS WIRE)–Dec. 21, 2018– Aimmune Therapeutics, Inc. (Nasdaq: AIMT), a biopharmaceutical company developing treatments for potentially life-threatening food allergies, today announced that it has submitted a Biologics License Application (BLA) to the U.S. Food and Drug Administration (FDA) for AR101, an investigational biologic oral immunotherapy for the treatment of peanut allergy in children and adolescents ages 4–17. The FDA […]

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News anchor opens up to viewers about dad’s stroke

Brooke Lennington’s phone buzzed late one night in 2016, a week before Thanksgiving. Her younger brother, Hunter, was calling, frantically saying a nurse at a hospital had called about their father. Hunter, a teenager, had been too overwhelmed to learn more. Brooke called and learned that then-50-year-old Rich Lennington had suffered a stroke. She asked how serious it was. “Honey, […]

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