Discovery of enhanced bone growth could lead to new treatments for osteoporosis

UCLA and UC San Francisco life scientists have discovered a dramatic pattern of bone growth in female mice—research that could potentially lead to stronger bone density in women and new treatments for osteoporosis in older women. The researchers found that blocking a particular set of signals from a small number of neurons in the brain causes female, but not male, […]

Continue reading »

Engineered immune cells target broad range of pediatric solid tumors in mice

Immune cells engineered to attack childhood cancers were able to eradicate different types of pediatric tumors in mice, according to a new study from the Stanford University School of Medicine. The study, which will be published online Jan. 17 in Clinical Cancer Research, provides evidence that these engineered cells can target many types of pediatric solid tumors, including brain tumors. […]

Continue reading »

Research team documents potential new treatment path for breast cancer

Immunotherapies that take off the “brakes” on the adaptive anti-tumor response have worked well in melanoma and lung cancer but less so in breast cancers. That could change. A Vanderbilt team led by John Wilson, assistant professor of chemical and biomolecular engineering, and Rebecca Cook, associate professor of cell and developmental biology, activated innate immunity in breast cancer cells and […]

Continue reading »

Breast cancer up to five times more likely to metastasize even 10 years after childbirth

A study by researchers at University of Colorado Cancer Center and Oregon Health & Science University published today in the Journal of the American Medical Association Network shows that breast cancers diagnosed in young women within 10 years of giving birth are more likely to metastasize, and thus more likely to cause death, than breast cancers in young women who […]

Continue reading »

New yeast model of metabolic disorders may lead to life-saving therapies

There are hundreds of metabolic disorders—including phenylketonuria, tyrosinemia, maple syrup urine disease and homocystinuria. These disorders lead to congenital diseases that produce a critical enzyme deficiency that interferes with the body’s metabolism. The pathologies and symptoms vary among the diseases, but all of them are usually fatal and have no known cure. Most metabolic disorders affect infants. The majority of […]

Continue reading »

How manganese produces a parkinsonian syndrome

Using X-ray fluorescence at synchrotrons DESY and ESRF, researchers in the Centre d’Etudes Nucléaires de Bordeaux Gradignan (CNRS/Université de Bordeaux) have demonstrated the consequences of a mutation responsible for a hereditary parkinsonian syndrome: accumulated manganese in the cells appears to disturb protein transport. This work, carried out with colleagues at the University of Texas at Austin (USA), was published in […]

Continue reading »

Developing a better, faster diagnostic for cryptosporidiosis

Cryptosporidiosis is the leading cause of waterborne diseases among humans in the United States, infecting almost 750,000 people each year, according to the Centers for Disease Control and Prevention. Globally in 2010, nearly 100,000 cases were fatal. The disease is of particular interest to Dr. Michael Riggs, a veterinarian and professor in the Department of Animal and Comparative Biomedical Sciences […]

Continue reading »
1 83 84 85 86 87 202