Autism-related genetic mutations occur in aging brains of Alzheimer’s patients

Researchers believe that autism is caused by mutations that occur sporadically in the egg or sperm or during pregnancy. Activity-dependent neuroprotective protein (ADNP) is a dominant gene whose de novo (during pregnancy) mutations are known to cause autism-related intellectual disabilities. A new Tel Aviv University study has found that ADNP mutations continue to occur in old age and accumulate in […]

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How an AI solution can design new tuberculosis drug regimens

With a shortage of new tuberculosis drugs in the pipeline, a software tool from the University of Michigan can predict how current drugs—including unlikely candidates—can be combined in new ways to create more effective treatments. “This could replace our traditional trial-and-error system for drug development that is comparatively slow and expensive,” said Sriram Chandrasekaran, U-M assistant professor of biomedical engineering, […]

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Trials promise good news for countries with dengue and Zika virus

An international team of scientists have reported an effective and environmentally sustainable way to block the transmission of mosquito-borne dengue virus, in trials carried out in Malaysia. The breakthrough has major implications for countries with hot climates such as island nations in the South Pacific to Saudi Arabia, Africa and South America, all of which experience dengue, Zika, yellow fever […]

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The high cost challenge of personalised screening for bowel cancer

Personalised screening could improve the diagnosis of bowel cancer and re-shape the future of Australia’s National Bowel Cancer Screening Program (NBCSP), according to new research at The University of Western Australia. The study, published today in Cancer Epidemiology, Biomarkers and Prevention, a journal of the American Association for Cancer Research, hopes to improve health outcomes by targeting screening at those […]

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Probing the role of an inflammation resolution sensor in obesity and heart failure

After heart attack injury, several fatty-acid-derived bioactive molecules—including one called resolvin D1—play an essential signaling role to safely clear inflammation and help repair heart muscle. The mechanism of how this resolution occurs is not well-understood. There is a receptor on the surface of many immune cells called ALX/FRP2, and in models of atherosclerosis, ALX/FPR2 is known to act as a […]

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