New rapid-fire method using pathology images, tumor data may help guide cancer therapies

By combining data on pathology images of 13 types of cancer and correlating that with clinical and genomic data, a Stony Brook University-led team of researchers are able to identify tumor-infiltrating lymphocytes (TILs), called TIL maps, which will enable cancer specialists to generate tumor-immune information from routinely gathered pathology slides. Published in Cell Reports , the paper details how TIL […]

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Early intervention may minimise later lung problems

A major study has found that controlling asthma through appropriate monitoring and medication is among several variables that can affect whether someone develops chronic obstructive pulmonary disease (COPD) in later life. The University of Melbourne-led study, published in The Lancet Respiratory Medicine, was the world’s first to characterise lung function trajectories that could lead to COPD in a large general […]

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Reducing severity of PTSD symptoms long-term holds significant public-health and economic implications

Both civilians and military veterans with post-traumatic stress disorder (PTSD) reap long-term benefits from psychotherapies used for short-term treatment, according to a new study from Case Western Reserve University. The findings suggest effective and lasting approaches for symptoms of PTSD—a debilitating and typically chronic disorder that rarely diminishes spontaneously and is associated with significant distress, impairment and considerable economic costs. […]

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Using mathematical models to determine the best chemotherapy schedules

Can mathematical models predict how can cancer cells respond to varied chemotherapy schedules? In other words, should cancers associated with fast-growing tumors, like brain cancer, be treated using a low drug dose administered continuously, as opposed to a high drug dose given periodically? Professor Paul Newton and Ph.D. recipient Jeffrey West have developed a tool that can predict the best […]

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Attention deficit disorders could stem from impaired brain coordination

Researchers from Case Western Reserve University School of Medicine and colleagues have discovered how two brain regions work together to maintain attention, and how discordance between the regions could lead to attention deficit disorders, including schizophrenia, bipolar disorder, and major depression. People with attention deficits have difficulty focusing and often display compulsive behavior. The new study suggests these symptoms could […]

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Injecting gene cocktail into mouse pancreas leads to humanlike tumors

Novel technology developed at UT Health San Antonio gives rise to mouse pancreatic tumors that have the same traits as human pancreatic cancer. A U.S. patent is pending on the invention. The technology could revolutionize studies of pancreatic cancer initiation and progression and spur new drug development. An article published in the journal Carcinogenesis (Oxford University Press) describes this unique […]

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Super drug-resistant gonorrhea coming to U.S., experts say

(HealthDay)—Americans should expect that a super-resistant form of gonorrhea like that found in the United Kingdom will soon reach these shores, health experts say. Earlier this year, doctors diagnosed a man in England with a case of gonorrhea that could not be cured with antibiotics commonly deployed against the sexually transmitted bacteria. This was shocking to the public, but not […]

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Primary care doctors may be unsure when kids’ bad moods are serious or not

All children have moments of moodiness, but family medicine doctors and pediatricians may doubt their abilities to tell the difference between normal irritability and possibly bigger issues, according to Penn State researchers. When the researchers interviewed a group of health care providers, they found that the primary care providers and pediatricians were less confident than the child and adolescent psychiatrists […]

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