Targeting the engine room of the cancer cell

Researchers at Columbia University Irving Medical Center (CUIMC) have developed a highly innovative computational framework that can support personalized cancer treatment by matching individual tumors with the drugs or drug combinations that are most likely to kill them. The study, published today on Nature Genetics, by Dr. Andrea Califano of Columbia University Irving Medical Center and Dr. Irvin Modlin of […]

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Microglia protect sensory cells needed for vision after retinal detachment

A research team at Massachusetts Eye and Ear has shown that microglia, the primary immune cells of the brain and retina, play a protective role in response to retinal detachment. Retinal detachment and subsequent degeneration of the retina can lead to progressive visual decline due to photoreceptor cell death, the major light-sensing cell in the eye. In a report published […]

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Electrically stimulating the brain may restore movement after stroke

UC San Francisco scientists have improved mobility in rats that had experienced debilitating strokes by using electrical stimulation to restore a distinctive pattern of brain cell activity associated with efficient movement. The researchers say they plan to use the new findings to help develop brain implants that might one day restore motor function in human stroke patients. After a stroke, […]

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Thrombectomy in acute stroke therapy feasible for very old patients, but not without risks

Mechanical thrombectomy is an increasingly important therapy for acute stroke that can also benefit the very old – assuming a careful selection of patients and risk assessment. This is a finding of a Portuguese study presented at the 4th Congress of the European Academy of Neurology (EAN) in Lisbon. For several years now, the endovascular thrombectomy has been a way […]

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Gene editing technology may improve accuracy of predicting individuals’ heart disease risk

Scientists may now be able to predict whether carrying a specific genetic variant increases a person’s risk for disease using gene editing and stem cell technologies, according to new research in the American Heart Association’s journal Circulation. For the first time, the study demonstrates the unique potential of combining stem cell-based disease modeling (Induced pluripotent stem cells) and CRISPR/Cas9-mediated genome […]

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To share or not to share? Physiological and social determinants of children’s sharing behavior

When are primary school children willing to share valuable resources with others and when are they not? A team of researchers from the University of Vienna led by cognitive biologist Lisa Horn investigated this question in a controlled behavioural experiment. The motivation to share seems to be influenced by group dynamical and physiological factors, whereas friendship between the children seems […]

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Early, intensive treatment of RA offers long-term benefits, may normalise mortality rates

The results of a 23-year, follow-up study presented today at the Annual European Congress of Rheumatology (EULAR 2018) suggest early, intensive treatment of rheumatoid arthritis has long-term benefits including the normalisation of mortality to levels consistent with the general population. “We know that the adverse effects of rheumatoid arthritis on the body only become truly apparent after more than a […]

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