Gene editing technology may improve accuracy of predicting individuals’ heart disease risk

Scientists may now be able to predict whether carrying a specific genetic variant increases a person’s risk for disease using gene editing and stem cell technologies, according to new research in the American Heart Association’s journal Circulation. For the first time, the study demonstrates the unique potential of combining stem cell-based disease modeling (Induced pluripotent stem cells) and CRISPR/Cas9-mediated genome […]

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Erectile dysfunction means increased risk for heart disease, regardless of other risk factors

Erectile dysfunction (ED) indicates greater cardiovascular risk, regardless of other risk factors, such as cholesterol, smoking and high blood pressure, according new research published in the American Heart Association’s journal Circulation. In the study, which followed more than 1,900 men, ages 60 to 78, over 4 years, those who reported ED were twice as likely to experience heart attacks, cardiac […]

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Mobile health technology can potentially transform how patients manage heart disease risk

Mobile health technology has the potential to transform the way we prevent and manage heart disease, but there are unanswered questions about how to optimize this technology and maintain engagement with patients, according to a review of randomized clinical trials published in the Canadian Journal of Cardiology. Cardiovascular disease is the leading cause of death worldwide. Recently, mobile health (mHealth) […]

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Job strain linked to increased risk of premature death for men with cardiometabolic disease

Having a demanding job and little control over it is associated with an increased risk of premature death in men with coronary heart disease, stroke, or diabetes, according to an observational study tracking more than 100000 men and women with and without cardiometabolic disease from Finland, France, Sweden, and the UK for almost 14 years, published in The Lancet Diabetes […]

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Common diabetes drug found safe for most diabetics with kidney disease

Results of a large-scale study suggest that the oral diabetes drug metformin is safe for most diabetics who also have chronic kidney disease (CKD). The study of more than 150,000 adults by Johns Hopkins Medicine investigators found that metformin’s association with the development of a life-threatening condition called lactic acidosis was seen only among patients with severely decreased kidney function. […]

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Metabolically ‘healthy’ obesity still linked to higher risk of cardiovascular disease

Women who are obese and who have been metabolically healthy for decades are still at higher risk of developing cardiovascular disease compared to metabolically healthy women of normal weight, according to an observational study that followed over 90000 American women for up to 30 years, published in The Lancet Diabetes & Endocrinology journal. The findings indicate that obesity is a […]

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Changes to specific MicroRNA involved in development of Lou Gehrig’s disease

A new Tel Aviv University study identifies a previously unknown mechanism involved in the development of Lou Gehrig’s disease, or amyotrophic lateral sclerosis (ALS). The research focuses on a specific microRNA whose levels were found to decrease as a result of ALS-causing muscular mutations. The study highlights, for the first time, the importance of toxic muscle-secreting molecules in the pathology […]

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Daily egg consumption may reduce cardiovascular disease

People who consume an egg a day could significantly reduce their risk of cardiovascular diseases compared with eating no eggs, suggests a study carried out in China, published in the journal Heart. Cardiovascular disease (CVD) is the leading cause of death and disability worldwide, including China, mostly due to ischaemic heart disease and stroke (including both haemorrhagic and ischaemic stroke). […]

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