Selective inhibitor shows early promise in patients with RET-altered cancers

BLU-667, a next-generation inhibitor that selectively targets the oncogenic receptor tyrosine kinase RET, was well tolerated and had broad clinical benefit in patients with advanced cancer that had progressed on previous therapies including multikinase inhibitor therapy. Proof-of-concept data will be presented from an ongoing phase I clinical trial at the AACR Annual Meeting 2018, April 14-18, in Chicago. “RET-altered cancers […]

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Sustained virological response to oral hepatitis C virus treatment associated with reduced mortality in Italian cohort

Patients with chronic hepatitis C virus (HCV) infection who achieve a sustained virological response (SVR) after direct-acting antiviral agent (DAA) treatment have lower all-cause mortality, according to a real-world study presented today at The International Liver Congress 2018 in Paris, France. The study, conducted in Italy, found that patients who achieved SVR were at reduced risk of death from both […]

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Punjab, India: Mass treatment of a population with chronic hepatitis C infection produces high rates of cure

A large-scale study evaluating the feasibility of decentralized care and the provision of free direct-acting antiviral agents (DAAs) has reported high rates of cure among a population of almost 20,000 individuals completing treatment for hepatitis C virus (HCV) infection. The study conducted in Punjab, India, which was reported today at The International Liver Congress 2018 in Paris, France, validated the […]

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A third of bacterial infections in patients with cirrhosis across the world are multi-drug resistant

A worldwide study initiated to investigate the epidemiology and outcomes of bacterial infections in hospitalized patients with liver cirrhosis has reported a prevalence of multi-drug-resistant (MDR) bacteria of 34% and significant regional differences in the risk of developing a multi-drug-resistant infection. Research teams from 46 centres across the world collaborated in this international study, which was promoted by the International […]

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Italy: Ongoing hepatitis A virus outbreak among men who have sex with men is linked to current outbreaks in Europe

Hepatitis A viruses (HAVs) circulating in an ongoing outbreak among men who have sex with men (MSM) in the Lombardy region of Italy are predominantly attributable to strains linked to two other recent outbreaks in Europe, according to a study presented today at The International Liver Congress 2018 in Paris, France. The study found that earlier cases in the Lombardy […]

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Kids with regular health care less likely to have life-threatening diabetic ketoacidosis

A key factor in reducing the risk of diabetic ketoacidosis (DKA), a potentially life-threatening complication of type 1 diabetes, in children at diagnosis of type 1 diabetes, is having a regular health care provider, according to a study in CMAJ (Canadian Medical Association Journal). Type 1 diabetes mellitus is a common chronic childhood disease. If untreated, it can result in […]

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Researchers advise long-term monitoring of infants infected with Zika after birth

A collaborative research team led by Ann Chahroudi, MD, PhD, of Emory University is recommending long-term clinical monitoring for infants infected with Zika virus early after birth. The recommendation is based on the team’s research results showing for the first time that postnatal Zika virus infection of rhesus macaque infants results in persistent abnormalities in brain structure and function as […]

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Gene-based tests may improve treatment for people with bipolar disorder

Bipolar affective disorder (BPAD) affects around 2% of the world’s population, leaving them with bouts of severe depression and episodes of what is commonly referred to as “mania”. A range of drug treatments are available, but choosing the right medication, or range of medications, can be a struggle – sometimes spanning many years. But new research aims to shorten this […]

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