Using light to fight GVHD

Extracorporeal photopheresis (ECP) is used to treat chronic graft-versus-host disease (cGVHD)—a complication of bone marrow or stem cell transplant that occurs when donor cells attack the recipient. How ECP works is unclear, and standardized treatment guidelines have not been established. Vanderbilt medical student Jocelyn Gandelman, Madan Jagasia, MBBS, and colleagues conducted a prospective, multicenter clinical trial of ECP for cGVHD. […]

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Is Keto Cycling Healthy? Here's What to Know About the Controversial Diet

Chances are, you’ve read about or know someone who’s on the keto diet, or perhaps you’ve experimented with it yourself. Short for “ketogenic,” the keto diet is an extremely low-carbohydrate eating plan that sends the body into ketosis—a state of burning fat for energy, rather than sugars. People on a ketogenic diet consume 50 grams or fewer of carbohydrates per day and […]

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Exposure to arsenic, lead, copper and cadmium linked to increased risk of heart disease

Exposure to arsenic, lead, copper and cadmium is associated with an increased risk of cardiovascular disease and coronary heart disease, finds a comprehensive analysis of the evidence published by The BMJ today. In recent years, exposure to environmental toxic metals such as arsenic, lead, copper, and mercury have become a major global health concern. Arsenic and cadmium, for example, are […]

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Genetic susceptibility to lower vitamin D levels and calcium intake not linked to fracture

Having a genetic predisposition to lower vitamin D levels and calcium intake is not associated with an increased risk of osteoporotic fracture, conclude researchers in The BMJ today. Their findings add to the ongoing debate over the benefits for the general population of vitamin D supplementation, which is recommended by clinical guidelines to prevent fractures. The findings also back recent […]

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Responding to cholera before it strikes

Research by University of Maryland microbiologist Rita Colwell is enabling a new British-led international aid effort to predict and stop potential epidemics of the disease cholera before they happen. This international effort, which has already begun in Yemen, draws on decades of Colwell’s work to understand the water-borne bacterium Vibrio cholerae that causes the disease, and uses a computer model […]

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New target could prevent progression of liver damage to cancer

Problems like obesity and alcoholism appear to chronically trigger in the liver a receptor known to amplify inflammation in response to invaders like bacteria, scientists report. The relentless, increased activity of TREM-1 in turn accelerates injury and scarring of the liver, a first step toward cirrhosis and liver cancer, says Dr. Anatolij Horuzsko, reproductive immunologist in the Georgia Cancer Center […]

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