6 Signs You Should Get Pre-Marital Counselling Before Tying the Knot

Premarital counseling is one of those things that’s strongly encouraged—or even required—if you’re getting married in a religious ceremony. But what happens if you’re not getting married in that kind of setting? Is this still something you should look into? Some experts say it’s super-helpful. Brandy Engler, a licensed clinical psychologist specialising in relationships, says counselling before you get hitched, […]

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Thrombectomy in acute stroke therapy feasible for very old patients, but not without risks

Mechanical thrombectomy is an increasingly important therapy for acute stroke that can also benefit the very old – assuming a careful selection of patients and risk assessment. This is a finding of a Portuguese study presented at the 4th Congress of the European Academy of Neurology (EAN) in Lisbon. For several years now, the endovascular thrombectomy has been a way […]

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Older melanoma patients have better response to immune checkpoint blockade therapy

Patient age correlates with response to immunotherapy in melanoma and depleting regulatory T cells in young patients may have a therapeutic potential to enhance response in younger patients, according to research from The Wistar Institute. Study results were published online in Clinical Cancer Research. Immune checkpoint blockade therapy has been recently approved for treatment of melanoma based on its ability […]

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Newly-approved therapy provides improved quality of life for midgut neuroendocrine tumor patients

Midgut neuroendocrine tumors are a rare type of cancer that develops in the small intestine and colon. Roughly 12,000 people are diagnosed with this disease each year. In January, the United Stated Food and Drug Administration approved Lutathera, a first-of-its-kind peptide receptor radionuclide therapy. The injection consists of a somatostatin analog combined with a radioactive isotope that directly targets neuroendocrine […]

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Resetting the epigenetic balance for cancer therapy

Though mutations in a gene called MLL3 are common across many types of cancers, their relationship to the development of the disease has been unclear. Now, a Northwestern Medicine study has identified an epigenetic imbalance that silences the expression of tumor-suppressing proteins, allowing cancerous cells to proliferate. In the study published in Nature Medicine, Northwestern investigators applied a simple molecular […]

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Trial identifies a medulloblastoma subset that requires less aggressive therapy

The youngest patients with the brain tumor medulloblastoma are among the most challenging because their rapidly developing brains limit treatment options. Now a team of researchers led by St. Jude Children’s Research Hospital have discovered a subtype that responds to a therapy that is less likely to cause long-term cognitive problems. The report appears today in the journal Lancet Oncology […]

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FDA approves CAR T therapy for large B-cell lymphoma

The U.S. Food and Drug Administration (FDA) has expanded approval for a personalized cellular therapy developed at the University of Pennsylvania’s Abramson Cancer Center, this time for the treatment of adult patients with relapsed or refractory large B-Cell lymphoma after two or more lines of systemic therapy. Today’s approval includes treatment of diffuse large B-cell lymphoma (DLBCL) – the most […]

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T cell biomarker predicts which CLL patients will respond to CAR T cell therapy

Penn Medicine researchers may have found the reason why some patients with advanced chronic lymphocytic leukemia (CLL) don’t respond to chimeric antigen receptor (CAR) T cell therapy, and the answer is tied to how primed patients’ immune systems are before the therapy is administered. While 80 percent of patients with advanced acute lymphoblastic leukemia (ALL) treated with the CAR T […]

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Three-minute version of brain stimulation therapy effective for hard-to-treat depression

In the largest study of its kind, a three-minute version of a brain stimulation treatment was shown to be just as effective as the standard 37-minute version for hard-to-treat depression. These results were published in a new Canadian study in The Lancet co-led by the Centre for Addiction and Mental Health (CAMH) and the University Health Network’s Krembil Research Institute, […]

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