Breast cancer could be prevented by targeting epigenetic proteins, study suggests

Researchers at the Princess Margaret Cancer Centre in Toronto have discovered that epigenetic proteins promote the proliferation of mammary gland stem cells in response to the sex hormone progesterone. The study, which will be published June 19 in the Journal of Cell Biology, suggests that inhibiting these proteins with drugs could prevent the development of breast cancer in women at […]

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Study finds behavioral-related youth hospitalizations complicated by suicidality

A recent study published in American Psychiatric Association’s Psychiatric Services journal found previous research on youth hospitalizations associated with behavioral and mental disorders failed to adequately consider children exhibiting suicidality or self-harm. Previous studies assigned behavioral health disorders, such as depression, as the primary diagnosis, while identifying suicidality or self-harm as a secondary diagnosis. By looking closely at the data, […]

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Study identifies protein’s role in mediating brain’s response to stress

A study led by Massachusetts General Hospital (MGH) investigators has identified a critical role for a protein called Kruppel-like factor 9 (Klf9) in the brain’s response to stress, which has implications for protecting against the effects of stress in conditions like major depression and post-traumatic stress disorder (PTSD). In their paper published in Cell Reports, the team describes finding that […]

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People more likely to trust, cooperate if they can tolerate ambiguity, study finds

Can a new colleague be trusted with confidential information? Will she be a cooperative team player on a critical upcoming project? Assessing someone’s motives or intentions, which are often hidden, is difficult, and gauging how to behave toward others involves weighing possible outcomes and personal consequences. New research published in Nature Communications indicates that individuals who are tolerant of ambiguity—a […]

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Study shows how intensive instruction changes brain circuitry in struggling readers

The early years are when the brain develops the most, forming neural connections that pave the way for how a child—and the eventual adult—will express feelings, embark on a task, and learn new skills and concepts. Scientists have even theorized that the anatomical structure of neural connections forms the basis for how children identify letters and recognize words. In other […]

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Hunger can lead to anger, but it’s more complicated than a drop in blood sugar, study says

What makes someone go from simply being hungry to full-on “hangry”? More than just a simple drop in blood sugar, this combination of hunger and anger may be a complicated emotional response involving an interplay of biology, personality and environmental cues, according to research published by the American Psychological Association. “We all know that hunger can sometimes affect our emotions […]

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Cattle may spread leptospirosis in Africa, study suggests

The bacterial infection leptospirosis is increasingly recognized as an important cause of fever in Africa. Now, researchers reporting in PLOS Neglected Tropical Diseases have analyzed the major risk factors for contracting leptospirosis and discovered that rice and cattle farming are associated with acute infection. Leptospirosis, caused by bacteria of the genus Leptospira, causes a wide range of symptoms and can […]

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Insurance denials for new hepatitis C drugs remain high nationwide, study suggests

Highly effective drugs that can cure chronic hepatitis C infection in approximately 95 percent of patients first became available in the U.S. in 2014. But both public and private insurers continue to deny coverage for these costly drugs at high rates nationwide, despite efforts to remove treatment restrictions, according to a new study published in Open Forum Infectious Diseases. The […]

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Study finds rare gain for tough-to-treat pancreatic cancer

Patients with pancreatic cancer that hadn’t spread lived substantially longer on a four-drug combo than on a single standard cancer drug, a rare advance for a tough-to-treat disease, researchers reported Monday. The results indicate the powerful chemotherapy treatment known as folfirinox will likely become standard of care for the minority of patients whose pancreatic cancer is diagnosed early enough to […]

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New study points to a potential ‘Achilles heel’ in brain cancer

Scientists at Virginia Commonwealth University believe they have uncovered an “Achilles heel” of glioblastoma multiforme (GBM), the most common and deadly form of brain cancer. Their study published this week in the Proceedings of the National Academy of Sciences details how a mechanism that protects glioma stem cells can potentially be exploited to develop new and more effective treatments for […]

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