New drug slashes death rates among drug-resistant TB patients: scientists

Credit: CC0 Public Domain A new treatment for a deadly drug-resistant strain of tuberculosis can cure more than 90 percent of sufferers, according to a landmark clinical trial whose results were revealed exclusively to AFP. Doctors in Belarus—a country with one of the world’s highest rates of multidrug-resistant tuberculosis—treated 181 patients with the new drug, bedaquiline, in combination with other […]

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Scientists uncover how rare gene mutation affects brain development and memory

Researchers from the University of California, Irvine School of Medicine, have found that a rare gene mutation alters brain development in mice, impairing memory and disrupting the communication between nerve cells. They also show memory problems could be improved by transplanting a specific type of nerve cell into the brain. The findings were published today in Neuron. “Mutations in hundreds […]

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Scientists examine how neuropathic pain responds to Metformin

Scientists seeking an effective treatment for one type of chronic pain believe a ubiquitous, generic diabetes medication might solve both the discomfort and the mental deficits that go with the pain. “People who are in constant pain have problems thinking straight sometimes. The longer you’re in pain, the more entrenched the impairment becomes,” said Stephanie Shiers, a fourth-year cognition and […]

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Scientists develop new drug treatment for tuberculosis

Scientists at The University of Manchester have developed the first non-antibiotic drug to successfully treat tuberculosis in animals. The team hope the compound -developed after 10 years of painstaking research will be trialled on humans within three to four years. The drug- which works by targeting Mycobacterium tuberculosis’ defences rather than the bacteria itself—can also take out its increasingly commonly […]

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Scientists develop new technique to heal large ulcers by reprogramming wound cells into skin cells

Plastic surgery to treat large cutaneous ulcers, including those seen in people with severe burns, bedsores or chronic diseases such as diabetes, may someday be a thing of the past. Scientists at the Salk Institute have developed a technique to directly convert the cells in an open wound into new skin cells. The approach relies on reprogramming the cells to […]

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Scientists engineer way to prevent immune response to gene therapy in mice

Stanford University School of Medicine researchers have demonstrated that gene therapy can be effective without causing a dangerous side effect common to all gene therapy: an autoimmune reaction to the normal protein, which the patient’s immune system is encountering for the first time. The researchers showed this in a mouse model that accurately recapitulates Duchenne muscular dystrophy. One in every […]

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Scientists tie specific brain circuit to sociability in mice

Social behavior in mouse models of autism spectrum disorder normalized when investigators triggered the release of a specific signaling substance, serotonin, in a single part of the animals’ brains, according to a study from the Stanford University School of Medicine. “This points to a previously understudied brain mechanism that contributes to an inability to derive pleasure from social interactions,” said […]

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