100-year-old scientific mystery solved: Researchers discover role of nuclear glycogen in non-small cell lung cancers

Researchers at the University of Kentucky Markey Cancer Center have made a breakthrough discovery that solves a mystery long forgotten by science and have identified a potentially novel avenue in pre-clinical models to treat non-small cell lung cancers. Published in Cell Metabolism, the research centers on the function of glycogen accumulation in the nucleus of a cell. Glycogen is known […]

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Uncovering possible role of polyphosphate in dialysis-related amyloidosis

Long-term dialysis treatment is tough on the body in many ways, but one of the most serious complications is dialysis-related amyloidosis, a disease characterized by abnormal buildup of protein aggregates—called amyloid fibrils—in joints, tissues and organs. Although there is no cure, recent research by Osaka University researchers sheds light on how amyloid fibrils form and aggregate, thereby allowing the identification […]

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Inherited mutations may play a role in pancreatic cancer development

A small, retrospective study has found that, in patients with particular pancreatic duct lesions, the presence of an inherited mutation in a pancreatic cancer susceptibility gene may increase the patients’ risk of developing pancreatic cancer. To verify these results and learn more about the development of this deadly cancer, the researchers recommend more genetic studies. Their hope—in line with the […]

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Kidney-resident macrophages—a role for healing during acute kidney injury?

During development in the womb, immune cells called macrophages go to the kidneys, and they remain there for life. Understanding the possible healing role for these macrophages after kidney damage may be crucial to helping treat patients who suffer acute kidney injury. Acute kidney injury, or AKI, is a devastating condition that develops in two-thirds of critically ill patients, and […]

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A role for microRNAs in social behavior

The recent discovery of microRNAs as key regulators of biological processes has fueled an explosion of research activity into their function in health and disease. Researchers have now uncovered a microRNA cluster that regulates synaptic strength and is involved in the control of social behaviour in mammals. The researchers presume that their discovery may point to new therapeutic strategies for […]

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Bug that causes stomach cancer could play a role in colorectal cancer

A bacterium known for causing stomach cancer might also increase the risk of certain colorectal cancers, particularly among African Americans, according to a study led by Duke Cancer Institute researchers. The finding, published online Oct. 5 in the journal Gastroenterology, describes an association between antibodies to H. pylori bacteria and an increased risk of colorectal cancers, although it does not […]

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Study identifies protein’s role in mediating brain’s response to stress

A study led by Massachusetts General Hospital (MGH) investigators has identified a critical role for a protein called Kruppel-like factor 9 (Klf9) in the brain’s response to stress, which has implications for protecting against the effects of stress in conditions like major depression and post-traumatic stress disorder (PTSD). In their paper published in Cell Reports, the team describes finding that […]

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Researchers describe role of novel mutations in fosfomycin resistance

Researchers identified novel chromosomal mutations and described their role in the development of resistance of Escherichia coli (E. coli) to broad-spectrum antibiotic fosfomycin, according to research presented at the 28th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID). Researchers from France studied the genetic basis of fosfomycin resistance in a panel of E. coli isolates and found that certain […]

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