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Arrhythmias—disruptions in the rhythm of the heartbeat—after congenital heart disease (CHD) surgery in children are common and contribute to increased morbidity and mortality. Prince Kannankeril, MD, MSCI, and colleagues explored clinical and genetic factors associated with atrial tachycardia (AT) after CHD surgery in infants younger than 1 year old. They examined variants in the genes PITX2 and IL6, which are […]
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(HealthDay)—A culturally specific, empowerment-based, and group-delivered behavioral prevention intervention can reduce sexual risk for HIV acquisition and transmission in sexually active young transgender women (YTW), according to a study published online Aug. 13 in JAMA Pediatrics. Robert Garofalo, M.D., M.P.H., from the Ann & Robert H. Lurie Children’s Hospital in Chicago, and colleagues conducted a randomized efficacy trial of a […]
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A research team led by Fergus Couch, Ph.D., a geneticist at Mayo Clinic, has identified specific genes associated with an increased risk for developing triple-negative breast cancer. Their research was published in the Journal of the National Cancer Institute. “Triple-negative breast cancer is an aggressive type of cancer that cannot be treated using targeted therapies,” says Dr. Couch. “It accounts […]
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Research led by Rinku Majumder, Ph.D., Associate Professor of Biochemistry at LSU Health New Orleans School of Medicine, has found how hypoxia (a low concentration of oxygen) decreases Protein S, a natural anticoagulant, resulting in an increased risk for the development of potentially life-threatening blood clots (thrombosis). Although hypoxia has been associated with an increased risk for thrombosis, this research […]
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(HealthDay)—Following quadrivalent human papillomavirus (HPV4) vaccination, girls age 12 to 17 years do not have increased risk of autoimmune disorders, according to a study published recently in CMAJ, the journal of the Canadian Medical Association. Erin Y. Liu, from Queen’s University in Kingston, Canada, and colleagues conducted a population-based retrospective cohort study using Ontario’s administrative health and vaccination databases from […]
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A single course of antibiotics early in childhood may increase risk for Type 1 diabetes. This is the finding of a study in mice led by researchers from NYU Medical School and published online July 24 in the journal eLife. The study centered on the intestinal microbiome, the mix of bacterial species that live in the digestive tract, and that […]
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Cardiovascular disease (CVD) is the leading cause of morbidity and mortality and also contributes to huge health care expenditures in China. Therefore, accurate and early identification of high-risk individuals is important for CVD prevention. The China-PAR (Prediction for atherosclerotic CVD (ASCVD) Risk in China) project generated equations with excellent capacity to predict lifetime risk for ASCVD by incorporating four large […]
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Research reported at the Alzheimer’s Association International Conference (AAIC) 2018 in Chicago highlighted sex differences associated with dementia and Alzheimer’s disease across the life course, including the first ever large-scale study of reproductive history and dementia risk in women. New results reported at AAIC 2018 suggest: Associations between dementia risk and number of children, number of miscarriages, age at first […]
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Researchers at Karolinska Institutet in Sweden report that sleep disturbances in midlife or in late life are associated with a higher risk for developing dementia in old age. The results are published in Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association. The results show that in midlife, when participants were in their 40s or 50s, insomnia was associated with […]
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For people with type 2 diabetes, switching to sulfonylurea drugs to control blood sugar levels is associated with an increased risk of complications compared with staying on the drug metformin, finds a study in The BMJ today. As such, the researchers say that continuing metformin when introducing sulfonylureas is safer than switching. Metformin is a “first-line” therapy (the first drug […]
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