progression Archives - Family Medicine News

Inflammatory processes drive progression of Alzheimer’s and other brain diseases

20.11.2019 Health Problems

Inflammation drives the progression of neurodegenerative brain diseases and plays a major role in the accumulation of tau proteins within neurons. An international research team led by the German Center for Neurodegenerative Diseases (DZNE) and the University of Bonn comes to this conclusion in the journal Nature. The findings are based on the analyses of human brain tissue and further […]

A better MRI marker for disability progression in multiple sclerosis

25.09.2019 Health Problems

A retrospective, five-year study of 1,314 patients with multiple sclerosis (MS) has found that atrophied brain lesion volume is the only marker from MRI scans that can accurately predict which patients will progress to the most severe form of the disease. Secondary progressive MS, known as SPMS, typically appears 10 to 20 years after the initial onset and causes patients […]

Amyloid is a less accurate marker for measuring severity, progression of Alzheimer’s

07.08.2019 Health Problems

While the presence of beta-amyloid plaques in the brain may be a hallmark of Alzheimer’s disease, giving patients an amyloid PET scan is not an effective method for measuring their cognitive function, according to a new study from researchers in the Perelman School of Medicine at the University of Pennsylvania and Thomas Jefferson University. The researchers concluded that fluorodeoxyglucose (FDG) […]

Calcifications in the eye increase risk for progression to advanced AMD by more than six times

09.11.2018 Health Problems

Calcified nodules in the retina are associated with progression to late stages of age-related macular degeneration (AMD). Experts from Queen’s University Belfast, working in partnership with the University of Alabama of Birmingham and in collaboration with UK material scientists and US clinical ophthalmology practices, made the ground-breaking discovery that the calcified nodules in the retina – the thin layer of […]

Suppression of DKK3 protein thwarts pancreatic tumor progression and prolongs survival

25.10.2018 Health Problems

Researchers at The University of Texas MD Anderson Cancer Center have shed new light on why pancreatic tumors are so resistant to therapy. The answer may lie in treating a protein found in the scar-type tissue called stroma which often surrounds the tumors. The tumor-associated stroma is comprised mostly of pancreatic stellate cells (PSCs) and its density and possibly the […]

New target could prevent progression of liver damage to cancer

27.08.2018 Health Problems

Problems like obesity and alcoholism appear to chronically trigger in the liver a receptor known to amplify inflammation in response to invaders like bacteria, scientists report. The relentless, increased activity of TREM-1 in turn accelerates injury and scarring of the liver, a first step toward cirrhosis and liver cancer, says Dr. Anatolij Horuzsko, reproductive immunologist in the Georgia Cancer Center […]

The cause of prostate cancer progression to the incurable stage has likely been uncovered

22.07.2018 Health Problems

Researchers at the University of Oulu in Finland have discovered novel genes and mechanisms that can explain how a genomic variant in a single nucleotide polymorphism (SNP) rs11672691 influences prostate cancer aggressiveness. Their findings also suggest ways to improve risk stratification and clinical treatment for advanced prostate cancer. The study is published in the journal Cell. Three billion base pairs […]

As brain extracts meaning from vision, study tracks progression of processing

10.07.2018 Health Problems

Here’s the neuroscience of a neglected banana (and a lot of other things in daily life): whenever you look at its color—green in the store, then yellow, and eventually brown on your countertop—your mind categorizes it as unripe, ripe, and then spoiled. A new study that tracked how the brain turns simple sensory inputs, such as “green,” into meaningful categories, […]

Alzheimer’s breakthrough: Brain metals that may drive disease progression revealed

21.06.2018 Health Problems

Alzheimer’s disease could be better treated, thanks to a breakthrough discovery of the properties of the metals in the brain involved in the progression of the neurodegenerative condition, by an international research collaboration including the University of Warwick. Dr. Joanna Collingwood, from Warwick’s School of Engineering, was part of a research team which characterised iron species associated with the formation […]

How a small molecule halts the spread of a toxic protein associated with Alzheimer’s progression

03.05.2018 Health Problems

Alzheimer’s disease destroys brain cells in part by promoting the formation of insoluble clumps that contain a protein called tau. Not only are these “tau aggregates” toxic for the cells that harbor them, but they also invade and destroy neighboring brain cells, or neurons, which speeds the cognitive decline associated with the Alzheimer’s. For those reasons, Alzheimer’s researchers have been […]

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