Calcifications in the eye increase risk for progression to advanced AMD by more than six times

Calcified nodules in the retina are associated with progression to late stages of age-related macular degeneration (AMD). Experts from Queen’s University Belfast, working in partnership with the University of Alabama of Birmingham and in collaboration with UK material scientists and US clinical ophthalmology practices, made the ground-breaking discovery that the calcified nodules in the retina – the thin layer of […]

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Suppression of DKK3 protein thwarts pancreatic tumor progression and prolongs survival

Researchers at The University of Texas MD Anderson Cancer Center have shed new light on why pancreatic tumors are so resistant to therapy. The answer may lie in treating a protein found in the scar-type tissue called stroma which often surrounds the tumors. The tumor-associated stroma is comprised mostly of pancreatic stellate cells (PSCs) and its density and possibly the […]

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New target could prevent progression of liver damage to cancer

Problems like obesity and alcoholism appear to chronically trigger in the liver a receptor known to amplify inflammation in response to invaders like bacteria, scientists report. The relentless, increased activity of TREM-1 in turn accelerates injury and scarring of the liver, a first step toward cirrhosis and liver cancer, says Dr. Anatolij Horuzsko, reproductive immunologist in the Georgia Cancer Center […]

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The cause of prostate cancer progression to the incurable stage has likely been uncovered

Researchers at the University of Oulu in Finland have discovered novel genes and mechanisms that can explain how a genomic variant in a single nucleotide polymorphism (SNP) rs11672691 influences prostate cancer aggressiveness. Their findings also suggest ways to improve risk stratification and clinical treatment for advanced prostate cancer. The study is published in the journal Cell. Three billion base pairs […]

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As brain extracts meaning from vision, study tracks progression of processing

Here’s the neuroscience of a neglected banana (and a lot of other things in daily life): whenever you look at its color—green in the store, then yellow, and eventually brown on your countertop—your mind categorizes it as unripe, ripe, and then spoiled. A new study that tracked how the brain turns simple sensory inputs, such as “green,” into meaningful categories, […]

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Alzheimer’s breakthrough: Brain metals that may drive disease progression revealed

Alzheimer’s disease could be better treated, thanks to a breakthrough discovery of the properties of the metals in the brain involved in the progression of the neurodegenerative condition, by an international research collaboration including the University of Warwick. Dr. Joanna Collingwood, from Warwick’s School of Engineering, was part of a research team which characterised iron species associated with the formation […]

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How a small molecule halts the spread of a toxic protein associated with Alzheimer’s progression

Alzheimer’s disease destroys brain cells in part by promoting the formation of insoluble clumps that contain a protein called tau. Not only are these “tau aggregates” toxic for the cells that harbor them, but they also invade and destroy neighboring brain cells, or neurons, which speeds the cognitive decline associated with the Alzheimer’s. For those reasons, Alzheimer’s researchers have been […]

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Index of tumor cells opens a new perspective to prevent cancer progression

Researchers from the School of Medicine in Ribeirão Preto (FMRP), at the University of São Paulo (USP), in collaboration with international groups, have developed indices that provide information about the prognosis of cancers, aid in the choice of the most appropriate therapy and identify potential targets for the development of new drugs. Their paper, titled “Machine Learning Identity Stemness Features […]

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