Study of acute myeloid leukemia patients shows protein inhibitor drug safe and effective with durable remissions

Ivosidenib, an experimental drug that inhibits a protein often mutated in several cancers has been shown to be safe, resulting in durable remissions, in a study of acute myeloid leukemia (AML) with relapsed or refractory disease. The multi-center Phase I trial, led by researchers at The University of Texas MD Anderson Cancer Center, was designed to determine ivosidenib’s safety and […]

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Conflicting guidance on opioid prescribing can jeopardize pain management for patients with cancer

Persistent pain and recurrent episodes of pain are common for those who are living with cancer, or for those undergoing cancer treatment. When used properly, prescription opioids have long been known to help combat pain experienced by people with cancer. In the face of the worsening opioid epidemic, clinical guidelines have been published by multiple agencies to improve the way […]

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Senior CA patients also benefit from palliative radiotherapy

(HealthDay)—All patients with painful bone metastasis should be referred for palliative radiotherapy to relieve the pain, regardless of age, according to a study published online May 23 in the Journal of Medical Imaging and Radiation Oncology. Jon Cacicedo, M.D., from Universitario Cruces/Biocruces Health Research Institute in Barakaldo, Spain, and colleagues evaluated whether age is a predictor of pain response after […]

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Survey finds 16 percent of burn patients test positive for PTSD

A Loyola Medicine survey has found that 15.8 percent of adult burn patients screened positive for post-traumatic stress disorder (PTSD). The survey by clinical psychologist Elizabeth Simmons, PsyD, licensed clinical social worker Kelly McElligott, AM, and colleagues from Loyola Medicine’s Burn Center was presented at the annual meeting of the American Burn Association, where it was named the top poster […]

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Extended INR test intervals safe for warfarin-treated patients

(HealthDay)—For stable warfarin-treated patients, extended international normalized ratio (INR) testing can be successfully and safely implemented, according to a study published online May 15 in the Journal of Thrombosis and Haemostasis. Geoffrey D. Barnes, M.D., from the University of Michigan in Ann Arbor, and colleagues identified patients as being eligible for extended INR testing based on prior INR value stability […]

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Dilemma for cancer patients as life-saving meds are tied to vision loss

(HealthDay)—A newer type of cancer treatment may offer the chance of longer survival, but the drugs could also trigger new side effects, such as vision problems. New research reports on three cases of a potentially vision-threatening eye condition called uveal effusion that patients developed after taking cancer immunotherapy. Immunotherapy uses a person’s own immune system to fight cancer. Uveal effusion […]

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Automated system better identifies patients at risk for ventilator-associated pneumonia

An automated system for identifying patients at risk for complications associated with the use of mechanical ventilators provided significantly more accurate results than did traditional surveillance methods, which rely on manual recording and interpretation of individual patient data. In their paper published in Infection Control & Hospital Epidemiology, a Massachusetts General Hospital (MGH) research team report that their system—using an […]

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