Gene study spots clues to heart risk for statin patients

A Vanderbilt-led research team has discovered genetic variations that increase the risk of heart attack even when patients are receiving a statin drug like Lipitor or Crestor to lower their blood cholesterol. The finding, published by the journal Circulation, helps explain why some patients experience a heart attack or the need for coronary revascularization to open blocked heart arteries while […]

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Study finds COPD patients are not learning how to properly use their inhaler devices

Inhaled medications play an important role in treating chronic obstructive pulmonary disease, or COPD, and it is imperative that the inhaler device be used properly to effectively treat the disease. However, in a recently released study in the Journal of the COPD Foundation, researchers from Baylor College of Medicine and other institutions found that healthcare providers and patients prioritize medication […]

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T cell biomarker predicts which CLL patients will respond to CAR T cell therapy

Penn Medicine researchers may have found the reason why some patients with advanced chronic lymphocytic leukemia (CLL) don’t respond to chimeric antigen receptor (CAR) T cell therapy, and the answer is tied to how primed patients’ immune systems are before the therapy is administered. While 80 percent of patients with advanced acute lymphoblastic leukemia (ALL) treated with the CAR T […]

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Obesity may hasten disability in patients with rheumatoid arthritis

In a study of adults with rheumatoid arthritis, those who were severely obese experienced more rapidly progressing disability than patients who were overweight. This was not explained by features of their arthritis, including the amount of inflammation in their joints. In the Arthritis Care & Research study, weight loss after enrollment was also associated with worsening disability, possibly as a […]

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Study shows a new approach to treating patients with stage IV Wilms tumor

A new study showing significantly improved survival rates for patients with stage IV Wilms tumors with lung metastases was recently published in the Journal of Clinical Oncology. The outcomes of the study, “Treatment of Stage IV Favorable Histology Wilms Tumor With Lung Metastases: A Report From the Children’s Oncology Group AREN0533 Study”, will be a game-changer in treating Wilms tumor […]

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Stories of child patients in early NHS unearthed

A University of Manchester historian is to highlight the untold experiences of children who were admitted to hospital in the early years of the NHS. In a special lecture on April 24 supported by the NHS Confederation—marking the NHS’s 70th anniversary of the launch of the National Health Service—Dr. Stephanie Snow will explore the human stories which define the NHS […]

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Selective inhibitor shows early promise in patients with RET-altered cancers

BLU-667, a next-generation inhibitor that selectively targets the oncogenic receptor tyrosine kinase RET, was well tolerated and had broad clinical benefit in patients with advanced cancer that had progressed on previous therapies including multikinase inhibitor therapy. Proof-of-concept data will be presented from an ongoing phase I clinical trial at the AACR Annual Meeting 2018, April 14-18, in Chicago. “RET-altered cancers […]

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A third of bacterial infections in patients with cirrhosis across the world are multi-drug resistant

A worldwide study initiated to investigate the epidemiology and outcomes of bacterial infections in hospitalized patients with liver cirrhosis has reported a prevalence of multi-drug-resistant (MDR) bacteria of 34% and significant regional differences in the risk of developing a multi-drug-resistant infection. Research teams from 46 centres across the world collaborated in this international study, which was promoted by the International […]

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Research suggests alternative treatment for beta blocker intolerant heart attack patients

Beta blockers have become a prescription drug staple for recovering heart attack patients. However, these blood pressure-reducing medications cannot be tolerated by many patients who are at higher risk for developing cardiovascular disease, including those with chronic obstructive pulmonary disease (COPD) and asthma, the elderly, and diabetics. As seen in the March 26 issue of Thyroid, researchers at New York […]

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Oral sirolimus alters the course of DIPNECH syndrome in three patients

Sirolimus, which is used to prevent rejection after kidney transplants, has been used to successfully treat three cases of a rare disorder called diffuse idiopathic pulmonary neuroendocrine cell hyperplasia, or DIPNECH syndrome. The syndrome is so rare that there are no clinical recommendations to guide care and, therefore, no proven therapies. The brief case report is published in Annals of […]

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