Researchers use ‘League of Legends’ to gain insights into mental models

Psychology researchers have used the game League of Legends to advance our understanding of how people build “mental models—the mental tools that allow people to make use of complex systems. The researchers found that mental models are developed in three distinct stages—findings that have the potential to inform everything from workplace training to video-game development. “We create mental models to […]

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Breast cancer: Discovery of a protein linked to metastasis

Jean-François Côté, a researcher at the Montreal Clinical Research Institute (IRCM) and professor at Université de Montréal’s Faculty of Medicine, studies metastasis, the leading cause of cancer-related death. Recently, his team uncovered a protein that, once deactivated, could prevent the development of metastases in an aggressive type of cancer, HER2-positive breast cancer. One in eight women will be diagnosed with […]

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Reduction in federal funding could reduce quality of specialized pediatric care

Hospitals caring for children with serious, chronic illness are highly dependent on public payers, according to a new study. The research found that proposals to dramatically reduce federal expenditures on Medicaid and Children’s Health Insurance Program (CHIP) could destabilize current specialty care referral networks serving all children, including the majority of privately-insured children in greatest need of high quality, specialized, […]

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High incidence of sudden and/or arrhythmic death in CHD

(HealthDay)—Among patients with coronary heart disease without severe systolic dysfunction, sudden and/or arrhythmic deaths (SAD) account for a considerable proportion of deaths, according to a study published online May 2 in JAMA Cardiology. Neal A. Chatterjee, M.D., from Brigham and Women’s Hospital in Boston, and colleagues conducted a cohort study involving 135 clinical sites with 5,761 participants with coronary heart […]

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How a small molecule halts the spread of a toxic protein associated with Alzheimer’s progression

Alzheimer’s disease destroys brain cells in part by promoting the formation of insoluble clumps that contain a protein called tau. Not only are these “tau aggregates” toxic for the cells that harbor them, but they also invade and destroy neighboring brain cells, or neurons, which speeds the cognitive decline associated with the Alzheimer’s. For those reasons, Alzheimer’s researchers have been […]

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Treating infectious disease with the help of antimicrobial peptides

Against the backdrop of increasing antibiotic resistance, the FORMAMP project has trialled nanotechnology-based delivery systems and antimicrobial peptides (AMPs), to deliver new tools in the fight against infectious diseases. It has been calculated that increased microbial resistance is responsible for an estimated 25 000 deaths per year, costing EUR 1.5 billion, across the EU. In the quest for new therapies […]

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New tools to boost the delivery of drugs to cancer tumours

The treatment of cancer tumours is made complex by their microenvironment and the abnormalities of the blood vessels sustaining them. The EU-funded NeoNaNo project has developed methods to improve drug delivery to tumours and improve the efficacy of anticancer therapy. Drug delivery to tumours is difficult. The blood vessels they depend on are abnormally structured, heterogeneously distributed and relatively poorly […]

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Brick by brick—assembly of the measles virus

Researchers have been able to capture images of measles viruses as they emerge from infected cells, using state of the art cryo-electron tomography techniques. The new images will help with a greater understanding of measles and related viruses, and could give hints on antiviral drug strategies likely to work across multiple viruses of this type. The results were published Monday, […]

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