Sepsis-3 criteria ‘preferable’ in prognostication of critically ill patients

For almost 30 years, diagnostic criteria for sepsis has used the Systemic Inflammatory Response Syndrome (SIRS) criteria in those with suspected infection, with presence of two or more criteria being diagnostic of sepsis. Recently, the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) re-evaluated these definitions and introduced the Sequential (Sepsis-related) Organ Failure Assessment (SOFA) score, with an […]

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Exercise may lower mortality in adult survivors of childhood CA

(HealthDay)—For adult survivors of childhood cancer, vigorous exercise in early adulthood is associated with reduced risk of mortality, according to a study published online June 3 in JAMA Oncology. Jessica M. Scott, Ph.D., from the Memorial Sloan Kettering Cancer Center in New York City, and colleagues conducted a multicenter cohort analysis among 15,450 adult cancer survivors diagnosed before age 21 […]

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A call to neuroscientists to help reveal root causes of chemobrain

A substantial fraction of non-central nervous system cancer survivors, especially those who have received chemotherapy, experience long-lasting cognitive difficulties, including problems with concentration, word-finding, short-term memory, and multitasking. Though well documented, cancer-related cognitive impairment (CRCI), known colloquially as chemobrain or chemofog, remains a mystery regarding its underlying neurological causes. In a Forum paper published June 12 in the journal Trends […]

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Newly-approved therapy provides improved quality of life for midgut neuroendocrine tumor patients

Midgut neuroendocrine tumors are a rare type of cancer that develops in the small intestine and colon. Roughly 12,000 people are diagnosed with this disease each year. In January, the United Stated Food and Drug Administration approved Lutathera, a first-of-its-kind peptide receptor radionuclide therapy. The injection consists of a somatostatin analog combined with a radioactive isotope that directly targets neuroendocrine […]

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Cancer: More targeted use of immunotherapy

Doctors are increasingly fighting cancer by stimulating patients’ immune systems. SNSF-supported researchers have now discovered a method for predicting the likelihood of treatment success. Immunotherapy changes a patient’s immune system to allow it to attack cancer cells and either destroy them or at least keep them from growing. But the therapy only works for a minority of patients. Researchers supported […]

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D-transposition of the great arteries—a new era in cardiology

In the current issue of Cardiovascular Innovations and Applications , Angeline D. Opina and Wayne J. Franklin from the Baylor College of Medicine and Texas Children’s Hospital, Houston, TX, USA consider the D-transposition of the great arteries. D-transposition of the great arteries (d-TGA) is the second most common cyanotic congenital heart disease (CHD) lesion, accounting for 3-5% of all CHD, […]

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New light shed on mechanisms of paediatric epilepsy

Research by Cardiff University has uncovered the brain activity that underlies absence epilepsy, offering new hope for the development of innovative therapies for this disabling disease. Absence epilepsy—the most common form of epilepsy in children and teenagers—causes episodes of lack of awareness which are often mistaken for daydreaming. The brain activity that causes this form of epilepsy has remained poorly […]

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Erectile dysfunction means increased risk for heart disease, regardless of other risk factors

Erectile dysfunction (ED) indicates greater cardiovascular risk, regardless of other risk factors, such as cholesterol, smoking and high blood pressure, according new research published in the American Heart Association’s journal Circulation. In the study, which followed more than 1,900 men, ages 60 to 78, over 4 years, those who reported ED were twice as likely to experience heart attacks, cardiac […]

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Science of racism examined in new set of research articles

White supremacist marches and xenophobic Twitter rants have brought overt racism to the center of public attention in recent months. Even still, subtle, structural, and systemic forms of racism continue to lurk in what is becoming an increasingly racially diverse United States. In a new collection of scholarly articles, psychological scientists describe research on the enduring and often hidden presence […]

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